Assessment of kidney function in chronic kidney disease by combining diffusion tensor imaging and total kidney volume

Objective This study aimed to investigate the value and feasibility of combining fractional anisotropy (FA) values from diffusion tensor imaging (DTI) and total kidney volume (TKV) for the assessment of kidney function in chronic kidney disease (CKD). Materials and methods Fifty-one patients were in...

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Bibliographic Details
Published in:International urology and nephrology 2022-02, Vol.54 (2), p.385-393
Main Authors: Li, Xue-Song, Zhang, Qing-Juan, Zhu, Jiang, Zhou, Qing-Qing, Yu, Yu-Sheng, Hu, Zhang-Chun, Xia, Zi-Yi, Wei, Liang, Yin, Xin-Dao, Zhang, Hong
Format: Article
Language:English
Subjects:
Aged
Anisotropy
Creatinine
Diffusion Tensor Imaging
Epidermal growth factor receptors
Feasibility Studies
Female
Humans
Kidney - diagnostic imaging
Kidney - pathology
Kidney - physiopathology
Kidney diseases
Magnetic resonance imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Nephrology - Original Paper
Neuroimaging
Organ Size
Renal Insufficiency, Chronic - diagnostic imaging
Renal Insufficiency, Chronic - pathology
Renal Insufficiency, Chronic - physiopathology
Urology
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Summary:Objective This study aimed to investigate the value and feasibility of combining fractional anisotropy (FA) values from diffusion tensor imaging (DTI) and total kidney volume (TKV) for the assessment of kidney function in chronic kidney disease (CKD). Materials and methods Fifty-one patients were included in this study. All MRI examinations were performed with a 3.0 T scanner. DTI was used to measure FA values, and TKV was obtained from DTI and T2-weighted imaging (T2WI). Patients were divided into three groups (mild, moderate, severe) according to eGFR, which was calculated with serum creatinine. Differences in the FA values of the cortex and medulla were analysed among the three groups, and the relationships of FA values, TKV, and the product of the FA values and TKV with eGFR were analysed. Receiver operating characteristic (ROC) curve analysis was used to compare the diagnostic efficiency of the FA values, TKV, and the product of the FA values and TKV for kidney function in different CKD stages. Results Medullary FA values (m-FA), TKV, and the product of the m-FA values and TKV (m-FA-TKV) were significantly correlated with eGFR ( r  = 0.653, 0.685, and 0.797, respectively; all P  
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-021-02886-8