Biomarkers of acute kidney injury in pediatric cardiac surgery

Acute kidney injury (AKI) is characterized by a sudden decrease in kidney function. Children with congenital heart disease are a special group at risk of developing AKI. We performed a systematic review of the literature to search for studies reporting the usefulness of novel urine, serum, and plasm...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2022, Vol.37 (1), p.61-78
Main Authors: Cavalcante, Candice Torres de Melo Bezerra, Cavalcante, Marcelo Borges, Castello Branco, Klebia Magalhães Pereira, Chan, Titus, Maia, Isabel Cristina Leite, Pompeu, Ronald Guedes, de Oliveira Telles, Andrea Consuelo, Brito, Anna Karina Martins, Libório, Alexandre Braga
Format: Article
Language:English
Subjects:
Acute Kidney Injury - diagnosis
Acute renal failure
Analysis
Biological markers
Biomarkers
Biomarkers - blood
Biomarkers - urine
Cardiac Surgical Procedures
Child
Children
Coronary artery disease
Cystatin C
Development and progression
Diagnosis
Diseases
Gelatinase
Heart
Heart Defects, Congenital - surgery
Heart diseases
Heart surgery
Humans
Interleukin 18
Kidneys
Leukocytes (neutrophilic)
Lipocalin
Literature reviews
Medicine
Medicine & Public Health
Nephrology
Pediatrics
Risk factors
Surgery
Systematic Review/Meta-analysis
Urology
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Summary:Acute kidney injury (AKI) is characterized by a sudden decrease in kidney function. Children with congenital heart disease are a special group at risk of developing AKI. We performed a systematic review of the literature to search for studies reporting the usefulness of novel urine, serum, and plasma biomarkers in the diagnosis and progression of AKI and their association with clinical outcomes in children undergoing pediatric cardiac surgery. In thirty studies, we analyzed the capacity to predict AKI and poor outcomes of five biomarkers: Cystatin C, Neutrophil gelatinase-associated lipocalin, Interleukin-18, Kidney injury molecule-1, and Liver fatty acid–binding protein. In conclusion, we suggest the need for further meta-analyses with the availability of additional studies.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-021-05094-9