GAB1‐ABL1 fusions in tumors that have histologic overlap with NTRK‐rearranged spindle cell tumors

Fibroblastic spindle cell tumors are a heterogeneous group of rare soft tissue tumors that are increasingly recognized as associated with a variety of kinase gene fusions. We report two cases of GAB1‐ABL1 fusions in spindle cell tumors that histologically overlap with neurotrophic tyrosine receptor...

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Bibliographic Details
Published in:Genes chromosomes & cancer 2021-09, Vol.60 (9), p.623-630
Main Authors: Choo, Florence, Rakheja, Dinesh, Davis, Lara E., Davare, Monika, Park, Jason Y., Timmons, Charles F., Neff, Tanaya, Beadling, Carol, Corless, Christopher L., Davis, Jessica L.
Format: Article
Language:English
Subjects:
ABL1
Abl1 gene
Adaptor Proteins, Signal Transducing - genetics
Aged
Antigens, CD34 - genetics
Antigens, CD34 - metabolism
Carcinoma - genetics
Carcinoma - pathology
CD34
CD34 antigen
Child
Collagen
Female
Humans
Imatinib
Mitosis
NTRK
Oncogene Proteins, Fusion - genetics
Proto-Oncogene Proteins c-abl - genetics
Receptor, trkC - genetics
S100
S100 Proteins - genetics
S100 Proteins - metabolism
Sarcoma
Soft Tissue Neoplasms - genetics
Soft Tissue Neoplasms - pathology
Targeted cancer therapy
Transcriptomes
Tumors
Tyrosine
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Summary:Fibroblastic spindle cell tumors are a heterogeneous group of rare soft tissue tumors that are increasingly recognized as associated with a variety of kinase gene fusions. We report two cases of GAB1‐ABL1 fusions in spindle cell tumors that histologically overlap with neurotrophic tyrosine receptor kinase (NTRK)‐rearranged spindle cell tumors. The first case occurred in a 76‐year‐old female who had a large deep‐seated spindle cell tumor composed of monotonous ovoid to spindle cells in a background of thick stromal collagen bands with prominent hyalinized vessels and inconspicuous mitoses (
ISSN:1045-2257
1098-2264
DOI:10.1002/gcc.22972