Hexane extract from Spiranthera odoratissima A. St.-hil. leaves: chemical composition and its bioactive potential against Candida pathogenic species, Leishmania amazonensis and Xylella fastidiosa

• Published in: Natural product research 2022-06, Vol.36 (11), p.2907-2912
• Main Authors: Souza, Amanda de O, Pereira, Paulo S, Fernandes, Cassia C, Andrade, Géssica, Pires, Regina H, Candido, Ana C B B, Magalhães, Lizandra G, Vieira, Tatiana M, Crotti, Antônio E M, Martins, Carlos H G, Miranda, Mayker L D
• Format: Article
• Language: English
• Subjects: Antibacterial activity; Antifungal Agents - chemistry; Antiprotozoal Agents - pharmacology; Cadinol; Candida; Candida glabrata; Caryophyllene; Caryophyllene oxide; Chemical composition; Fungicides; Hexanes; Leishmania; Leishmania mexicana; Microbial Sensitivity Tests; Minimum inhibitory concentration; Oils, Volatile - chemistry; Pain; Plant Leaves - chemistry; Rutaceae; Spathulenol; Volatile compounds; Xylella; Xylella fastidiosa
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2021.1931188

A. St.-Hil. (Rutaceae) has been popularly used against abdominal pain and rheumatism. This study aimed at extracting hexane from (HE-SO) leaves to identify and quantify its volatile compounds by GC-MS and GC-FID and to evaluate its antifungal, antileishmanial and antibacterial activities . HE-SO exhibited antileishmanial activity against promastigote forms of (IC = 38.16 µg/mL) and was moderately active against (MIC = 100 µg/mL). HE-SO also showed remarkable antifungal potential against six strains species, i. e., , , , , and . The lowest MIC values were between 31.25 and 250 µg/mL. Spathulenol (20.2%), τ-cadinol (11.7%), α-cadinol (9.4%), caryophyllene oxide (9.2%) and isoaromadendrene epoxide (8.2%) were the major components identified in HE-SO. Therefore, results showed that HE-SO has promising antileishmanial and antifungal actions.