Evaluation of anaesthetic depth and cardiopulmonary effects of propofol infusion rate in Sapajus apella previously chemically contained with dextroketamine‐midazolam

Background This study evaluated the cardiopulmonary effects and anaesthetic depth induced by a propofol infusion rate of 0.8 mg/kg/min in monkeys (Sapajus apella). Materials and methods Five capuchin monkeys received dextroketamine‐midazolam intramuscularly. After a maximum duration of 5 min, the va...

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Published in:Journal of medical primatology 2021-08, Vol.50 (4), p.207-211
Main Authors: Gomes, Viviane Horta, Silva, Marta Fernanda Albuquerque, Carregaro, Adriano Bonfim, Oliveira, Renato Leão Sá, Neves, Daniel Marchesi
Format: Article
Language:English
Subjects:
alkylphenol
anaesthesia
anaesthetic recovery
Anesthesia
benzodiazepines
Blood pressure
capuchin monkey
Catheters
dissociative anaesthesia
general anaesthesia
Hypotension
Midazolam
Muscle contraction
non‐human primate
Physiology
Propofol
Sapajus apella
side effects
TIVA
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Summary:Background This study evaluated the cardiopulmonary effects and anaesthetic depth induced by a propofol infusion rate of 0.8 mg/kg/min in monkeys (Sapajus apella). Materials and methods Five capuchin monkeys received dextroketamine‐midazolam intramuscularly. After a maximum duration of 5 min, the values of the physiological parameters were recorded, and a venous catheter was placed. After recovery from chemical restraint, the animals were anaesthetized with propofol intravenously, which was maintained for 1 h. Physiological parameters, anaesthetic depth, the time and quality of anaesthetic recovery were evaluated. Results Heart and respiratory rates, systolic blood pressure and rectal temperature during propofol infusion were lower than those during anaesthesia induction with dextroketamine‐midazolam. Unconsciousness, muscle relaxation and lack of response to tail clamping were observed during propofol infusion. No animals showed excitement or vocalization during anaesthetic recovery. Conclusion Propofol infusion rate of 0.8 mg/kg/min promoted surgical general anaesthesia, with transient hypotension, which showed excellent anaesthetic recovery.
ISSN:0047-2565
1600-0684
DOI:10.1111/jmp.12529