Management of the major complications of cirrhosis: Beyond guidelines

Along with a growing understanding of the pathophysiology of cirrhosis and its complications, new therapies and management strategies have emerged in recent years. Many of these advances have helped inform the current EASL clinical practice guidelines1 on the management of some of the key complicati...

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Bibliographic Details
Published in:Journal of hepatology 2021-07, Vol.75, p.S135-S146
Main Authors: Garcia-Pagan, Juan Carlos, Francoz, Claire, Montagnese, Sara, Senzolo, Marco, Mookerjee, Rajeshwar P.
Format: Article
Language:English
Subjects:
Cirrhosis
Controversies
Decompensation
Guidelines
Humans
Liver Cirrhosis - complications
Liver Cirrhosis - physiopathology
Liver Cirrhosis - therapy
Management
Patient Care Management - methods
Patient Care Management - standards
Practice Guidelines as Topic
Preventive Health Services - methods
Preventive Health Services - trends
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Summary:Along with a growing understanding of the pathophysiology of cirrhosis and its complications, new therapies and management strategies have emerged in recent years. Many of these advances have helped inform the current EASL clinical practice guidelines1 on the management of some of the key complications of cirrhosis, such as ascites, variceal bleeding and infection. However, there are still some aspects of management where the evidence base is less clear, and/or where opinions amongst practitioners remain divided. Some of these more controversial areas are explored in this section, wherein we present evidence culminating in a suggested management approach based on expert opinion and extending beyond the current guidelines.
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2021.01.027