Rheumatic Fever and Rheumatic Heart Disease in the United States

During the 1920s, acute rheumatic fever (ARF) was the leading cause of mortality in children in the United States. By the 1980s, many felt ARF had all but disappeared from the US. However, although ARF and rheumatic heart disease (RHD) rates remain low in the US today, disease burden is unequal and...

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Bibliographic Details
Published in:Pediatric annals 2021-03, Vol.50 (3), p.e98-e104
Main Authors: de Loizaga, Sarah R., Beaton, Andrea Z.
Format: Article
Language:English
Subjects:
Age
Antigens
At Risk Persons
Cardiovascular disease
Clinical Diagnosis
Disease prevention
Epidemics
Etiology
Heart
Heart Disorders
Infections
Malayo Polynesian Languages
Medical Services
Pathogenesis
Pathogens
Patients
Rheumatic fever
Streptococcus infections
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Summary:During the 1920s, acute rheumatic fever (ARF) was the leading cause of mortality in children in the United States. By the 1980s, many felt ARF had all but disappeared from the US. However, although ARF and rheumatic heart disease (RHD) rates remain low in the US today, disease burden is unequal and tracks along other disparities of cardiovascular health. It is estimated that 1% to 3% of patients with untreated group A streptococcus (GAS) infection, most typically GAS pharyngitis, will develop ARF, and of these, up to 60% of cases will result in chronic RHD. This article reviews the epidemiology, pathogenesis, diagnosis, and management of ARF/RHD to increase awareness of ARF/RHD for clinicians based in the US. [ Pediatr Ann. 2021;50(3):e98–e104.]
ISSN:0090-4481
1938-2359
DOI:10.3928/19382359-20210221-01