Quantification of glycoproteins by nuclear magnetic resonance associated with preclinical carotid atherosclerosis in patients with type 1 diabetes

• Published in: Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2021-06, Vol.31 (7), p.2099-2108
• Main Authors: Serés-Noriega, Tonet, Giménez, Marga, Perea, Verónica, Blanco, Jesús, Vinagre, Irene, Pané, Adriana, Ruiz, Sabina, Cofán, Monserrat, Mesa, Alex, Esmatjes, Enric, Conget, Ignacio, Ortega, Emilio, Amor, Antonio J.
• Format: Article
• Language: English
• Subjects: Atherosclerosis; Cardiovascular risk; Carotid ultrasonography; Glycoproteins; NMR-Glycoproteins; Type 1 diabetes
• ISSN: 0939-4753; 1590-3729
• DOI: 10.1016/j.numecd.2021.03.021

Glycoproteins play a key role in inflammatory and cardiometabolic processes. Their implication in atherosclerosis in type 1 diabetes (T1D) is unknown. We assessed the relationships between classic inflammatory markers, glycoproteins measured by nuclear magnetic resonance (1H-NMR), and preclinical atherosclerosis in these patients. We selected patients with T1D, without cardiovascular disease (CVD), with: age ≥40 years, nephropathy (micro/macroalbuminuria), or ≥10 years of evolution with another risk factor. The presence of plaque (intima-media thickness >1.5 mm) was determined by ultrasonography. Concentrations of high-sensitive C-reactive protein (hsCRP), circulating leukocytes (classical inflammation markers) and 1H-NMR-glycoproteins (GlycA, GlycB, GlycF, and the height/width [H/W] ratios of GlycA and GlycB) were determined. We included 189 patients (58% male, age 47.0 [40.7–55.2] years). Thirty-five percent presented plaques (22%, ≥2 plaques). There was no association between hsCRP or leukocytes and atherosclerosis. However, in age- and sex-adjusted models, GlycA, GlycF, and the H/W ratios of GlycA and GlycB gradually increased with the number of plaques (0, 1, ≥2 plaques) only in patients without statins (p