Dietary vitamin D intake and colorectal cancer risk: a longitudinal approach within the PREDIMED study

Purpose We evaluated whether the intake of dietary vitamin D is associated with the incidence of both colorectal cancer (CRC) and colon cancer in the framework of the PREDIMED cohort of older adults at high cardiovascular risk. Methods We analyzed data from 7216 men and women (55–80 years) without C...

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Bibliographic Details
Published in:European journal of nutrition 2021-12, Vol.60 (8), p.4367-4378
Main Authors: Hernández-Alonso, Pablo, Canudas, Silvia, Boughanem, Hatim, Toledo, Estefanía, Sorlí, Jose V., Estruch, Ramón, Castañer, Olga, Lapetra, José, Alonso-Gómez, Angel M., Gutiérrez-Bedmar, Mario, Fiol, Miquel, Serra-Majem, Lluis, Pintó, Xavier, Ros, Emilio, Fernandez-Lazaro, Cesar I., Ramirez-Sabio, Judith B., Fitó, Montse, Portu-Zapirain, Joseba, Macias-González, Manuel, Babio, Nancy, Salas-Salvadó, Jordi
Format: Article
Language:English
Subjects:
Cardiovascular diseases
Chemistry
Chemistry and Materials Science
Colon cancer
Colorectal cancer
Colorectal carcinoma
Diet
Dietary intake
Energy intake
Nutrition
Original Contribution
Vitamin D
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Summary:Purpose We evaluated whether the intake of dietary vitamin D is associated with the incidence of both colorectal cancer (CRC) and colon cancer in the framework of the PREDIMED cohort of older adults at high cardiovascular risk. Methods We analyzed data from 7216 men and women (55–80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Baseline consumption of vitamin D was assessed using a validated 137-item food frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC and colon cancer incidence were estimated for quartiles and per 1-SD of baseline vitamin D intake. Results During a median follow-up of 6 years, we documented 97 incident CRC cases after the exclusion of subjects with no baseline dietary data and/or outliers of energy intake. A non-significant HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme quartiles (4th vs 1st) of vitamin D intake were observed [0.55 (0.30–1.00), P for trend = 0.072], whereas it was significant for colon cancer incidence alone [0.44 (0.22–0.90), P for trend = 0.032]. However, this association became significant in CRC and colon cancer incidence, after excluding 391 subjects consuming baseline vitamin D and/or calcium medication or prescribed supplements [0.52 (0.28–0.96) and 0.41 (0.12–0.85), respectively]. Conclusion A higher dietary intake of vitamin D was significantly associated with a reduced CRC risk in individuals at high cardiovascular risk.
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-021-02585-1