The physical and mental burden of dry eye disease: A large population-based study investigating the relationship with health-related quality of life and its determinants

This large cross-sectional population-based study investigated the relationship between dry eye disease (DED) and health-related quality of life (HR-QoL). Dry eye and HR-QoL were assessed in 78,165 participants (19–94 yrs, 59.2% female) from the Dutch population-based Lifelines cohort, using the WHS...

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Bibliographic Details
Published in:The ocular surface 2021-07, Vol.21, p.107-117
Main Authors: Morthen, Mathias Kaurstad, Magno, Morten Schjerven, Utheim, Tor Paaske, Snieder, Harold, Hammond, Christopher J., Vehof, Jelle
Format: Article
Language:English
Subjects:
Burden
Dry eye disease
Health-related quality of life (HR-QoL)
Mental
Physical
Quality of life
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Summary:This large cross-sectional population-based study investigated the relationship between dry eye disease (DED) and health-related quality of life (HR-QoL). Dry eye and HR-QoL were assessed in 78,165 participants (19–94 yrs, 59.2% female) from the Dutch population-based Lifelines cohort, using the WHS and the SF36 questionnaire, respectively. Logistic regression was used to assess the relationship between DED and below median Physical Component Summary (PCS) and Mental Component Summary (MCS) score, corrected for age, sex, education, BMI, and 52 comorbidities. Overall, 8.9% of participants had DED. Participants with DED had an increased risk of low PCS (OR 1.54 (95% CI 1.46–1.62)) and MCS scores (OR 1.39 (95% CI 1.32–1.46)), corrected for age and sex. This risk remained significant after correction for comorbidities (P 
ISSN:1542-0124
1937-5913
DOI:10.1016/j.jtos.2021.05.006