Major histocompatibility complex (MHC) class I and class II proteins: impact of polymorphism on antigen presentation

The major histocompatibility complex (MHC) loci are amongst the most polymorphic regions in the genomes of vertebrates. In the human population, thousands of MHC gene variants (alleles) exist that translate into distinct allotypes equipped with overlapping but unique peptide binding profiles. Unders...

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Bibliographic Details
Published in:Current opinion in immunology 2021-06, Vol.70, p.95-104
Main Authors: Abualrous, Esam T, Sticht, Jana, Freund, Christian
Format: Article
Language:English
Subjects:
Antigen Presentation - genetics
Antigen Presentation - immunology
Histocompatibility Antigens Class I - genetics
Histocompatibility Antigens Class I - immunology
Histocompatibility Antigens Class II - genetics
Histocompatibility Antigens Class II - immunology
Humans
Polymorphism, Genetic - genetics
Polymorphism, Genetic - immunology
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Summary:The major histocompatibility complex (MHC) loci are amongst the most polymorphic regions in the genomes of vertebrates. In the human population, thousands of MHC gene variants (alleles) exist that translate into distinct allotypes equipped with overlapping but unique peptide binding profiles. Understanding the differential structural and dynamic properties of MHC alleles and their interaction with critical regulators of peptide exchange bears the potential for more personalized strategies of immune modulation in the context of HLA-associated diseases.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2021.04.009