Molecular allergology and its impact in specific allergy diagnosis and therapy

Progressive knowledge of allergenic structures resulted in a broad availability of allergenic molecules for diagnosis. Component‐resolved diagnosis allowed a better understanding of patient sensitization patterns, facilitating allergen immunotherapy decisions. In parallel to the discovery of allerge...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2021-12, Vol.76 (12), p.3642-3658
Main Authors: Barber, Domingo, Diaz‐Perales, Araceli, Escribese, Maria M., Kleine‐Tebbe, Jörg, Matricardi, Paolo M., Ollert, Markus, Santos, Alexandra F., Sastre, Joaquin
Format: Article
Language:English
Subjects:
allergen immunotherapy
Allergens
Allergies
component‐resolved diagnosis
Desensitization, Immunologic - methods
Diagnosis
Food allergies
food allergy
Humans
Hypersensitivity - diagnosis
Hypersensitivity - therapy
Immunoglobulin E
Immunotherapy
major allergen
Medical diagnosis
respiratory allergy
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Summary:Progressive knowledge of allergenic structures resulted in a broad availability of allergenic molecules for diagnosis. Component‐resolved diagnosis allowed a better understanding of patient sensitization patterns, facilitating allergen immunotherapy decisions. In parallel to the discovery of allergenic molecules, there was a progressive development of a regulation framework that affected both in vitro diagnostics and Allergen Immunotherapy products. With a progressive understanding of underlying mechanisms associated to Allergen immunotherapy and an increasing experience of application of molecular diagnosis in daily life, we focus in analyzing the evidences of the value provided by molecular allergology in daily clinical practice, with a focus on Allergen Immunotherapy decisions.
ISSN:0105-4538
1398-9995
DOI:10.1111/all.14969