Non-cytotoxic organic–inorganic hybrid bioscaffolds: An efficient bedding for rapid growth of bone-like apatite and cell proliferation

Synthesis and characterization of organic–inorganic macroporous hybrid scaffolds were investigated. The materials were prepared by combining 2-hydroxyethylmethacrylate (HEMA) and triethoxyvinylsilane (TEVS) chemically modified by Ca2+ and PO43− ions via sol–gel route. In this study we have construct...

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Bibliographic Details
Published in:Materials Science & Engineering C 2012-10, Vol.32 (7), p.1849-1858
Main Authors: John, Łukasz, Bałtrukiewicz, Marta, Sobota, Piotr, Brykner, Renata, Cwynar-Zając, Łucja, Dzięgiel, Piotr
Format: Article
Language:English
Subjects:
Apatite
Biomineralization
Bone tissue engineering
Bones
Cell proliferation
Composite
Hydroxyapatite
Materials science
Networks
Regenerative
Scaffold
Scaffolds
Scanning electron microscopy
Spectroscopy
Three dimensional
Topography
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Summary:Synthesis and characterization of organic–inorganic macroporous hybrid scaffolds were investigated. The materials were prepared by combining 2-hydroxyethylmethacrylate (HEMA) and triethoxyvinylsilane (TEVS) chemically modified by Ca2+ and PO43− ions via sol–gel route. In this study we have constructed a sugar-based cracks-free three-dimensional (3D) network with interconnected porous architecture within the range of 150–300μm and rough topography. The obtained results revealed that both topography and composition of prepared materials allow rapid growth of the bone-like apatite (HAp) layer on their surface after soaking in biological medium. Preliminary studies have shown that hybrids covered by HAp are non-cytotoxic and allow cell proliferation that make them a promising scaffolds in the field of bone regenerative medicine. The materials were mainly characterized by powder X-ray diffraction analysis (PXRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy–energy-dispersive spectroscopy (SEM–EDS) and transmission electron microscopy–energy-dispersive spectroscopy (TEM–EDS). [Display omitted] ► Sol–gel derived biomaterials. ► 3D organic–inorganic hybrid composites for bone tissue engineering. ► Sugar-templated cracks-free macroporous scaffolds. ► 2-hydroxyethylmethacrylate/triethoxyvinylsilane blend doped with calcium and phosphate ions. ► Non-cytotoxic bedding for fibroblasts proliferation.
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2012.05.002