Silver Catalyzed Decarbonylative 3 + 2 Cycloaddition of Cyclobutenediones and Formamides

• Published in: Molecules (Basel, Switzerland) Switzerland), 2021-05, Vol.26 (10)
• Main Authors: Wang, Pengcheng, Yu, Ruirui, Ali, Sajjad, Wang, Zhengshen, Liu, Zhigang, Gao, Jinming, Zheng, Huaiji
• Format: Article
• Language: English
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules26102974

As an important moiety in natural products, N,O-acetal has attracted wide attention in the past few years. An efficient method to construct N,O-acetal has been developed. Using silver catalyst, cyclobutenediones were smoothly converted to the corresponding γ-aminobutenolides in the presence of formamides, in which cyclobutenediones likely proceed with a key decarbonylative [3 + 2] cycloaddition process. In this way, a series of products with varied substituents were isolated in moderate yield and fully characterized.As an important moiety in natural products, N,O-acetal has attracted wide attention in the past few years. An efficient method to construct N,O-acetal has been developed. Using silver catalyst, cyclobutenediones were smoothly converted to the corresponding γ-aminobutenolides in the presence of formamides, in which cyclobutenediones likely proceed with a key decarbonylative [3 + 2] cycloaddition process. In this way, a series of products with varied substituents were isolated in moderate yield and fully characterized.