Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia

Evidence indicate that 1 h post-load glucose levels (1hPG) ≥ 155 mg/dl identify amongst subjects with normal glucose tolerance (NGT) a new category of prediabetes (NGT 1 h-high). A compromised myocardial mechano-energetic efficiency (MEE) is associated with type 2 diabetes and predicts adverse cardi...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2021-07, Vol.177, p.108883-108883, Article 108883
Main Authors: Vanessa Fiorentino, Teresa, Miceli, Sofia, Succurro, Elena, Sciacqua, Angela, Andreozzi, Francesco, Sesti, Giorgio
Format: Article
Language:English
Subjects:
1h post-load glucose
Cardiac energetics
Cardiovascular disease
Impaired fasting glucose
Impaired glucose tolerance
Myocardial energetic efficiency
Prediabetes
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Summary:Evidence indicate that 1 h post-load glucose levels (1hPG) ≥ 155 mg/dl identify amongst subjects with normal glucose tolerance (NGT) a new category of prediabetes (NGT 1 h-high). A compromised myocardial mechano-energetic efficiency (MEE) is associated with type 2 diabetes and predicts adverse cardiovascular outcomes. Herein, we explored the association between prediabetes conditions such as NGT 1 h-high, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and a decreased MEE. MEE was assessed by an echocardiography-derived measure in 1467 non-diabetic individuals subdivided according to their glucose tolerance: NGT and 1-hPG 
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2021.108883