Chemerin activity in selected pathological states of human body – A systematic review

Recent studies have revealed that fatty tissue, so far considered an energy storage organ, is also the source of many substances called adipokines, including chemerin which plays many important functions in the body. Chemerin stimulates adipocytes maturation and differentiation, as well as acts as a...

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Bibliographic Details
Published in:Advances in medical sciences 2021-09, Vol.66 (2), p.270-278
Main Authors: Acewicz, Magdalena, Kasacka, Irena
Format: Article
Language:English
Subjects:
Adipocytes
Adipokines
Chemerin
Chemokines
Human Body
Humans
Inflammatory process
Intercellular Signaling Peptides and Proteins
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Summary:Recent studies have revealed that fatty tissue, so far considered an energy storage organ, is also the source of many substances called adipokines, including chemerin which plays many important functions in the body. Chemerin stimulates adipocytes maturation and differentiation, as well as acts as a chemoattractant, which stimulates innate and acquired immunity. This adipokine participates in the early stages of acute inflammation as well as its suppression by reacting with the CMKLR1 receptor. In various diseases associated with inflammatory processes, the level of chemerin in the serum increases. It is also considered a marker for benign and malignant tumors. Explanation of the pathomechanisms involving this adipokine is of a high importance and may contribute to the development of new possibilities in the treatment of many diseases. The article presents the latest information on the role of chemerin in various pathological states, particularly in psoriasis.
ISSN:1896-1126
1898-4002
DOI:10.1016/j.advms.2021.05.002