Hyaluronic acid hydrogels reinforced with laser spun bioactive glass micro- and nanofibres doped with lithium

The repair of articular cartilage lesions in weight-bearing joints remains as a significant challenge due to the low regenerative capacity of this tissue. Hydrogels are candidates to repair lesions as they have similar properties to cartilage extracellular matrix but they are unable to meet the mech...

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Published in:Materials Science & Engineering C 2021-07, Vol.126, p.112124-112124, Article 112124
Main Authors: Riveiro, Antonio, Amorim, Sara, Solanki, Anu, Costa, Diana S., Pires, Ricardo A., Quintero, Félix, del Val, Jesús, Comesaña, Rafael, Badaoui, Aida, Lusquiños, Fernando, Maçon, Anthony L.B., Tallia, Francesca, Jones, Julian R., Reis, Rui L., Pou, Juan
Format: Article
Language:English
Subjects:
Bioactive glass
Bioglass
Biological activity
Cartilage
Cartilage (articular)
Cell proliferation
Composite materials
Extracellular matrix
Fibers
Glass fiber reinforced plastics
Glass fibers
Hyaluronic acid
Hydrogel
Hydrogels
Laser spinning
Lesions
Lithium
Materials science
Mechanical properties
Modulus of elasticity
Nanofibers
Repair
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Summary:The repair of articular cartilage lesions in weight-bearing joints remains as a significant challenge due to the low regenerative capacity of this tissue. Hydrogels are candidates to repair lesions as they have similar properties to cartilage extracellular matrix but they are unable to meet the mechanical and biological requirements for a successful outcome. Here, we reinforce hyaluronic acid (HA) hydrogels with 13-93-lithium bioactive glass micro- and nanofibres produced by laser spinning. The glass fibres are a reinforcement filler and a platform for the delivery of therapeutic lithium-ions. The elastic modulus of the composites is more than three times higher than in HA hydrogels. Modelling of the reinforcement corroborates the experimental results. ATDC5 chondrogenic cells seeded on the composites are viable and more proliferation occurs on the hydrogels containing fibres than in HA hydrogels alone. Furthermore, the chondrogenic behavior on HA constructs with fibres containing lithium is more marked than in hydrogels with no-lithium fibres. [Display omitted] •Lithium-doped bioactive glass micro-and nanofibers produced by laser spinning.•Hyaluronic acid hydrogels mechanically reinforced with bioactive glass micro- and nanofibers.•Elastic properties of hydrogels more than triplicated•Lithium ions released from bioactive glass micro- and nanofibers promote the chondrogenic behavior of ATDC5 cells.•Hydrogel composite shows potential application in regeneration of subchondral defects.
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2021.112124