Impact of radiobiological models on the calculation of the therapeutic parameters of Grid therapy for breast cancer

Therapeutic advantages of Grid therapy have been demonstrated in several theoretical studies using the standard linear-quadratic (LQ) model. However, the suitability of the LQ model when describing cell killing at highly modulated radiation fields has been questioned. In this study, we have applied...

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Bibliographic Details
Published in:Applied radiation and isotopes 2021-08, Vol.174, p.109776-109776, Article 109776
Main Authors: Mahmoudi, Farshid, Chegeni, Nahid, Bagheri, Ali, Fatahi Asl, Jafar, Batiar, Mohammad Taghi
Format: Article
Language:English
Subjects:
Breast cancer
Breast Neoplasms - radiotherapy
Bystander effect
Female
Grid therapy
Humans
Linear Models
Monte Carlo Method
Radiobiological model
Radiobiology
Radiotherapy - methods
Therapeutic ratio
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Summary:Therapeutic advantages of Grid therapy have been demonstrated in several theoretical studies using the standard linear-quadratic (LQ) model. However, the suitability of the LQ model when describing cell killing at highly modulated radiation fields has been questioned. In this study, we have applied an extended LQ model to recalculate therapeutic parameters of Grid therapy. This study shows that incorporating the bystander effects in the radiobiological models would significantly change the theoretical predictions and conclusion of Grid therapy, especially at high dose gradient fields. •The main parts of a 6-MV linac along with various Grid blocks was modeled via Geant4 Monte Carlo code.•Both the standard and extended LQ models were employed to calculate the therapeutic ratio and geometric sparing factor.•The standard LQ model predicts a lower value for the TR and a higher value for the GSF, compared to the extended model.•The discrepancy between the standard and extended LQ models significantly increases with the dose gradient in GRID therapy.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2021.109776