Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics

• Published in: Advanced drug delivery reviews 2021-08, Vol.175, p.113823-113823, Article 113823
• Main Authors: Mehta, Prina, Rasekh, Manoochehr, Patel, Mohammed, Onaiwu, Ekhoerose, Nazari, Kazem, Kucuk, I., Wilson, Philippe B., Arshad, Muhammad Sohail, Ahmad, Zeeshan, Chang, Ming-Wei
• Format: Article
• Language: English
• Subjects: Biomedical; Biomedical Engineering - methods; Centrifugal spinning; Centrifugation; Drug delivery; Drug Delivery Systems - methods; Electromagnetic Phenomena; Electrospinning; Fiber engineering; Humans; Materials Science - methods; Nanofibers; Nanotechnology; Precision Medicine - methods; Pressure; Pressurised gyration; Regenerative medicine; Regenerative Medicine - methods; Tissue engineering
• ISSN: 0169-409X; 1872-8294
• DOI: 10.1016/j.addr.2021.05.033

[Display omitted] •Use of fibers in various remits has increased in recent years.•In sync with nanotechnology, fibrous structure engineering methods have advanced.•Novel fiber fabrication methods overcome limitations of conventional technologies.•Fibers of micro/nanometer size are valuable in drug delivery and regenerative medicine. Advancements in technology and material development in recent years has led to significant breakthroughs in the remit of fiber engineering. Conventional methods such as wet spinning, melt spinning, phase separation and template synthesis have been reported to develop fibrous structures for an array of applications. However, these methods have limitations with respect to processing conditions (e.g. high processing temperatures, shear stresses) and production (e.g. non-continuous fibers). The materials that can be processed using these methods are also limited, deterring their use in practical applications. Producing fibrous structures on a nanometer scale, in sync with the advancements in nanotechnology is another challenge met by these conventional methods. In this review we aim to present a brief overview of conventional methods of fiber fabrication and focus on the emerging fiber engineering techniques namely electrospinning, centrifugal spinning and pressurised gyration. This review will discuss the fundamental principles and factors governing each fabrication method and converge on the applications of the resulting spun fibers; specifically, in the drug delivery remit and in regenerative medicine.