Evaluation of the progression of non-azotemic proteinuric chronic kidney disease in dogs

Proteinuria is a recognized risk factor for progression of canine chronic kidney disease (CKD). However, the prognosis of non-azotemic proteinuric CKD in dogs has been studied only to a limited extent. Moreover, the degree to which proteinuria should be decreased to delay CKD progression remains unk...

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Bibliographic Details
Published in:Research in veterinary science 2021-09, Vol.138, p.11-18
Main Authors: Miyakawa, H., Ogawa, M., Sakatani, A., Akabane, R., Miyagawa, Y., Takemura, N.
Format: Article
Language:English
Subjects:
Albumins
Biochemistry
Biopsy
Blood pressure
Canine
Creatinine
Dogs
Kidney diseases
Kidneys
Medical prognosis
Medical records
Non-azotemia
Protein losing nephropathy
Proteinuria
Risk analysis
Risk factors
Statistical analysis
Urinalysis
Urine
Urine albumin-creatinine ratio
Veterinary medicine
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Summary:Proteinuria is a recognized risk factor for progression of canine chronic kidney disease (CKD). However, the prognosis of non-azotemic proteinuric CKD in dogs has been studied only to a limited extent. Moreover, the degree to which proteinuria should be decreased to delay CKD progression remains unknown. The purposes of this study were (1) to identify factors associated with disease progression and (2) to investigate the degree of proteinuria, albuminuria, and blood pressure during the course of treatment associated with the progression using time-averaged urine protein:creatinine ratio (UPC) and urine albumin:creatinine ratio (UAC) in canine non-azotemic proteinuric CKD. Twenty-one dogs with non-azotemic proteinuric CKD were included in the study. High UPC and UAC were associated with CKD progression (P 
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2021.05.018