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68Ga-PSMA-11 PET/CT in patients with occult biochemical recurrence of prostate carcinoma and negative 18F-Choline PET/CT. Preliminary assessment of its clinical use
To assess the clinical usefulness of 68Ga-PSMA PET/CT studies in patients with occult biochemical recurrence of prostate carcinoma, with negative or inconclusive radiologic and 18 F-Choline PET/CT imaging studies. Retrospective descriptive study. The first 14 patients with a history of prostate carc...
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| Published in: | Actas urológicas españolas (English ed.) 2021-06, Vol.45 (5), p.353-358 |
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| creator | Plaza López, P.J. Puertas, E. Aguiló, J.J. Suarez-Piñera, M. Domenech, B. Mestre-Fusco, A. Casals, J. Chicharo de Fleitas, J.R. |
| description | To assess the clinical usefulness of 68Ga-PSMA PET/CT studies in patients with occult biochemical recurrence of prostate carcinoma, with negative or inconclusive radiologic and 18 F-Choline PET/CT imaging studies.
Retrospective descriptive study. The first 14 patients with a history of prostate carcinoma, treated with curative intent and presenting suspicion of biochemical recurrence with low PSA values ( |
| doi_str_mv | 10.1016/j.acuroe.2021.04.008 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2537640968</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2173578621000548</els_id><sourcerecordid>2537640968</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1848-79bc99a7cd4e9a5a7be34d437109c3c574b31e8283a6c978343aa51378e4404a3</originalsourceid><addsrcrecordid>eNp9kTFv2zAQhYWiBRqk-QcdOGaRQoqUSC0BDCNJCziogbozcT6daxoS6ZBSivyf_tDScYZM5XIc3r0P715RfBW8Ely0N4cKcI6BqprXouKq4tx8KC5qoWXZaNN-fPf_XFyldOD5tUo2nbwo_rbmAcr1z8dFKQRb321ulhvmPDvC5MhPif1x054FxHmY2NYF3NPoEAYWKVMjeSQWduwYQ5pgIoYQ0fkwAgPfM0-_s88zMWHuy-U-DM7TG6Ri60iDG52H-MIgJUppzMSTm8tczNpX0JzoS_FpB0Oiq7d5Wfy6v9ssv5WrHw_fl4tVicIoU-pui10HGntFHTSgtyRVr6QWvEOJjVZbKcjURkKLnTZSSYBGSG1IKa5AXhbXZ98c52mmNNnRJaRhAE9hTrZupG4V71qTpeosxZw8RdrZY3RjjmIFt6de7MGee7GnXixXNveS127Pa5RjPDuKNqE7HbF3-aCT7YP7v8E_BPeXww</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2537640968</pqid></control><display><type>article</type><title>68Ga-PSMA-11 PET/CT in patients with occult biochemical recurrence of prostate carcinoma and negative 18F-Choline PET/CT. Preliminary assessment of its clinical use</title><source>ScienceDirect Freedom Collection</source><creator>Plaza López, P.J. ; Puertas, E. ; Aguiló, J.J. ; Suarez-Piñera, M. ; Domenech, B. ; Mestre-Fusco, A. ; Casals, J. ; Chicharo de Fleitas, J.R.</creator><creatorcontrib>Plaza López, P.J. ; Puertas, E. ; Aguiló, J.J. ; Suarez-Piñera, M. ; Domenech, B. ; Mestre-Fusco, A. ; Casals, J. ; Chicharo de Fleitas, J.R.</creatorcontrib><description>To assess the clinical usefulness of 68Ga-PSMA PET/CT studies in patients with occult biochemical recurrence of prostate carcinoma, with negative or inconclusive radiologic and 18 F-Choline PET/CT imaging studies.
Retrospective descriptive study. The first 14 patients with a history of prostate carcinoma, treated with curative intent and presenting suspicion of biochemical recurrence with low PSA values (<3 ng/mL) were selected. Imaging studies, prostate ultrasound, pelvic CT and/or MRI were negative, and all of them had a negative or inconclusive 18F-Choline PET/CT.
All patients were referred to 68 Ga-PSMA-11 PET/CT. Protocol: Dose 2.2 M Bq/kg. 20 mg furosemide at start. PET/CT images from skull base to proximal third of thighs at 60 min, and late images at 3 h if needed.
The 68 Ga-PSMA-11 PET/CT was able to localize the occult biochemical recurrence in 9 of the 14 patients (64.2%), and it affected the therapeutic attitude in all of them.
Four patients (28.5%) obtained a negative or inconclusive 68 Ga-PSMA-11 PET/CT and continued under vigilant approach with PSA controls and imaging studies according to the clinical guidelines. These patients had the lowest PSA values (less than 1 ng/mL).
One of the 68 Ga-PSMA-11 PET/CT studies was inconclusive, reporting the presence of a doubtful right iliac adenopathy.
68 Ga-PSMA-11 PET/CT allows an early diagnosis, with low PSA values, of occult biochemical recurrence of prostate carcinoma, even in patients with negative 18 F-Choline PET/CT.
Valorar la utilidad de los estudios PET/TC 68Ga-PSMA en la práctica clínica de los pacientes con recidiva bioquímica oculta de carcinoma de próstata, con estudios de imagen radiológicos y PET/TC 18F-Colina negativos o no concluyentes.
Estudio descriptivo retrospectivo. Se seleccionaron los primeros 14 pacientes con antecedentes de carcinoma de próstata, tratados con intención curativa y que presentaban sospecha de recidiva bioquímica con valores bajos de PSA (<3 ng/mL). Los estudios de imagen, ecografía prostática, TC y/o RM pélvica eran negativos, y todos ellos tenían un PET/TC 18F-Colina negativo o no concluyente. Se derivó a todos los pacientes para realizarse un 68 Ga-PSMA-11PET/TC. Protocolo: Dosis 2.2 M Bq/Kg. 20 mg de furosemida en el minuto 0. Imágenes PET/TC desde calota craneal hasta tercio proximal de muslos a los 60 min, e imágenes tardías a las 3 horas si precisara.
: En 9 de los 14 pacientes (64.2%) el 68 Ga-PSMA-11PET/TC consiguió localizar la recidiva bioquímica oculta, y en todos ellos hubo cambios en la actitud terapéutica. En 4 de los 14 pacientes (28.5%) el 68 Ga-PSMA-11PET/TC resultó negativo o no concluyente, se prosiguió con la actitud vigilante con controles de PSA y estudios de imagen según los protocolos habituales. Estos pacientes presentaban los valores más bajos de PSA (inferiores a 1 ng/mL). Uno de los estudios 68 Ga-PSMA-11PET/TC fue no concluyente, informándose la presencia de una dudosa adenopatía iliaca derecha.
El 68 Ga-PSMA-11PET/TC permite un diagnóstico precoz, con valores bajos de PSA, de la recidiva bioquímica oculta del carcinoma de próstata, incluso en pacientes con 18F-Colina PET/TC negativos.</description><identifier>ISSN: 2173-5786</identifier><identifier>EISSN: 2173-5786</identifier><identifier>DOI: 10.1016/j.acuroe.2021.04.008</identifier><language>eng</language><publisher>Elsevier España, S.L.U</publisher><subject>PET/CT ; PET/TC ; Prostate cancer ; PSMA</subject><ispartof>Actas urológicas españolas (English ed.), 2021-06, Vol.45 (5), p.353-358</ispartof><rights>2021 AEU</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1848-79bc99a7cd4e9a5a7be34d437109c3c574b31e8283a6c978343aa51378e4404a3</citedby><cites>FETCH-LOGICAL-c1848-79bc99a7cd4e9a5a7be34d437109c3c574b31e8283a6c978343aa51378e4404a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Plaza López, P.J.</creatorcontrib><creatorcontrib>Puertas, E.</creatorcontrib><creatorcontrib>Aguiló, J.J.</creatorcontrib><creatorcontrib>Suarez-Piñera, M.</creatorcontrib><creatorcontrib>Domenech, B.</creatorcontrib><creatorcontrib>Mestre-Fusco, A.</creatorcontrib><creatorcontrib>Casals, J.</creatorcontrib><creatorcontrib>Chicharo de Fleitas, J.R.</creatorcontrib><title>68Ga-PSMA-11 PET/CT in patients with occult biochemical recurrence of prostate carcinoma and negative 18F-Choline PET/CT. Preliminary assessment of its clinical use</title><title>Actas urológicas españolas (English ed.)</title><description>To assess the clinical usefulness of 68Ga-PSMA PET/CT studies in patients with occult biochemical recurrence of prostate carcinoma, with negative or inconclusive radiologic and 18 F-Choline PET/CT imaging studies.
Retrospective descriptive study. The first 14 patients with a history of prostate carcinoma, treated with curative intent and presenting suspicion of biochemical recurrence with low PSA values (<3 ng/mL) were selected. Imaging studies, prostate ultrasound, pelvic CT and/or MRI were negative, and all of them had a negative or inconclusive 18F-Choline PET/CT.
All patients were referred to 68 Ga-PSMA-11 PET/CT. Protocol: Dose 2.2 M Bq/kg. 20 mg furosemide at start. PET/CT images from skull base to proximal third of thighs at 60 min, and late images at 3 h if needed.
The 68 Ga-PSMA-11 PET/CT was able to localize the occult biochemical recurrence in 9 of the 14 patients (64.2%), and it affected the therapeutic attitude in all of them.
Four patients (28.5%) obtained a negative or inconclusive 68 Ga-PSMA-11 PET/CT and continued under vigilant approach with PSA controls and imaging studies according to the clinical guidelines. These patients had the lowest PSA values (less than 1 ng/mL).
One of the 68 Ga-PSMA-11 PET/CT studies was inconclusive, reporting the presence of a doubtful right iliac adenopathy.
68 Ga-PSMA-11 PET/CT allows an early diagnosis, with low PSA values, of occult biochemical recurrence of prostate carcinoma, even in patients with negative 18 F-Choline PET/CT.
Valorar la utilidad de los estudios PET/TC 68Ga-PSMA en la práctica clínica de los pacientes con recidiva bioquímica oculta de carcinoma de próstata, con estudios de imagen radiológicos y PET/TC 18F-Colina negativos o no concluyentes.
Estudio descriptivo retrospectivo. Se seleccionaron los primeros 14 pacientes con antecedentes de carcinoma de próstata, tratados con intención curativa y que presentaban sospecha de recidiva bioquímica con valores bajos de PSA (<3 ng/mL). Los estudios de imagen, ecografía prostática, TC y/o RM pélvica eran negativos, y todos ellos tenían un PET/TC 18F-Colina negativo o no concluyente. Se derivó a todos los pacientes para realizarse un 68 Ga-PSMA-11PET/TC. Protocolo: Dosis 2.2 M Bq/Kg. 20 mg de furosemida en el minuto 0. Imágenes PET/TC desde calota craneal hasta tercio proximal de muslos a los 60 min, e imágenes tardías a las 3 horas si precisara.
: En 9 de los 14 pacientes (64.2%) el 68 Ga-PSMA-11PET/TC consiguió localizar la recidiva bioquímica oculta, y en todos ellos hubo cambios en la actitud terapéutica. En 4 de los 14 pacientes (28.5%) el 68 Ga-PSMA-11PET/TC resultó negativo o no concluyente, se prosiguió con la actitud vigilante con controles de PSA y estudios de imagen según los protocolos habituales. Estos pacientes presentaban los valores más bajos de PSA (inferiores a 1 ng/mL). Uno de los estudios 68 Ga-PSMA-11PET/TC fue no concluyente, informándose la presencia de una dudosa adenopatía iliaca derecha.
El 68 Ga-PSMA-11PET/TC permite un diagnóstico precoz, con valores bajos de PSA, de la recidiva bioquímica oculta del carcinoma de próstata, incluso en pacientes con 18F-Colina PET/TC negativos.</description><subject>PET/CT</subject><subject>PET/TC</subject><subject>Prostate cancer</subject><subject>PSMA</subject><issn>2173-5786</issn><issn>2173-5786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kTFv2zAQhYWiBRqk-QcdOGaRQoqUSC0BDCNJCziogbozcT6daxoS6ZBSivyf_tDScYZM5XIc3r0P715RfBW8Ely0N4cKcI6BqprXouKq4tx8KC5qoWXZaNN-fPf_XFyldOD5tUo2nbwo_rbmAcr1z8dFKQRb321ulhvmPDvC5MhPif1x054FxHmY2NYF3NPoEAYWKVMjeSQWduwYQ5pgIoYQ0fkwAgPfM0-_s88zMWHuy-U-DM7TG6Ri60iDG52H-MIgJUppzMSTm8tczNpX0JzoS_FpB0Oiq7d5Wfy6v9ssv5WrHw_fl4tVicIoU-pui10HGntFHTSgtyRVr6QWvEOJjVZbKcjURkKLnTZSSYBGSG1IKa5AXhbXZ98c52mmNNnRJaRhAE9hTrZupG4V71qTpeosxZw8RdrZY3RjjmIFt6de7MGee7GnXixXNveS127Pa5RjPDuKNqE7HbF3-aCT7YP7v8E_BPeXww</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Plaza López, P.J.</creator><creator>Puertas, E.</creator><creator>Aguiló, J.J.</creator><creator>Suarez-Piñera, M.</creator><creator>Domenech, B.</creator><creator>Mestre-Fusco, A.</creator><creator>Casals, J.</creator><creator>Chicharo de Fleitas, J.R.</creator><general>Elsevier España, S.L.U</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202106</creationdate><title>68Ga-PSMA-11 PET/CT in patients with occult biochemical recurrence of prostate carcinoma and negative 18F-Choline PET/CT. Preliminary assessment of its clinical use</title><author>Plaza López, P.J. ; Puertas, E. ; Aguiló, J.J. ; Suarez-Piñera, M. ; Domenech, B. ; Mestre-Fusco, A. ; Casals, J. ; Chicharo de Fleitas, J.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1848-79bc99a7cd4e9a5a7be34d437109c3c574b31e8283a6c978343aa51378e4404a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>PET/CT</topic><topic>PET/TC</topic><topic>Prostate cancer</topic><topic>PSMA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Plaza López, P.J.</creatorcontrib><creatorcontrib>Puertas, E.</creatorcontrib><creatorcontrib>Aguiló, J.J.</creatorcontrib><creatorcontrib>Suarez-Piñera, M.</creatorcontrib><creatorcontrib>Domenech, B.</creatorcontrib><creatorcontrib>Mestre-Fusco, A.</creatorcontrib><creatorcontrib>Casals, J.</creatorcontrib><creatorcontrib>Chicharo de Fleitas, J.R.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Actas urológicas españolas (English ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plaza López, P.J.</au><au>Puertas, E.</au><au>Aguiló, J.J.</au><au>Suarez-Piñera, M.</au><au>Domenech, B.</au><au>Mestre-Fusco, A.</au><au>Casals, J.</au><au>Chicharo de Fleitas, J.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>68Ga-PSMA-11 PET/CT in patients with occult biochemical recurrence of prostate carcinoma and negative 18F-Choline PET/CT. Preliminary assessment of its clinical use</atitle><jtitle>Actas urológicas españolas (English ed.)</jtitle><date>2021-06</date><risdate>2021</risdate><volume>45</volume><issue>5</issue><spage>353</spage><epage>358</epage><pages>353-358</pages><issn>2173-5786</issn><eissn>2173-5786</eissn><abstract>To assess the clinical usefulness of 68Ga-PSMA PET/CT studies in patients with occult biochemical recurrence of prostate carcinoma, with negative or inconclusive radiologic and 18 F-Choline PET/CT imaging studies.
Retrospective descriptive study. The first 14 patients with a history of prostate carcinoma, treated with curative intent and presenting suspicion of biochemical recurrence with low PSA values (<3 ng/mL) were selected. Imaging studies, prostate ultrasound, pelvic CT and/or MRI were negative, and all of them had a negative or inconclusive 18F-Choline PET/CT.
All patients were referred to 68 Ga-PSMA-11 PET/CT. Protocol: Dose 2.2 M Bq/kg. 20 mg furosemide at start. PET/CT images from skull base to proximal third of thighs at 60 min, and late images at 3 h if needed.
The 68 Ga-PSMA-11 PET/CT was able to localize the occult biochemical recurrence in 9 of the 14 patients (64.2%), and it affected the therapeutic attitude in all of them.
Four patients (28.5%) obtained a negative or inconclusive 68 Ga-PSMA-11 PET/CT and continued under vigilant approach with PSA controls and imaging studies according to the clinical guidelines. These patients had the lowest PSA values (less than 1 ng/mL).
One of the 68 Ga-PSMA-11 PET/CT studies was inconclusive, reporting the presence of a doubtful right iliac adenopathy.
68 Ga-PSMA-11 PET/CT allows an early diagnosis, with low PSA values, of occult biochemical recurrence of prostate carcinoma, even in patients with negative 18 F-Choline PET/CT.
Valorar la utilidad de los estudios PET/TC 68Ga-PSMA en la práctica clínica de los pacientes con recidiva bioquímica oculta de carcinoma de próstata, con estudios de imagen radiológicos y PET/TC 18F-Colina negativos o no concluyentes.
Estudio descriptivo retrospectivo. Se seleccionaron los primeros 14 pacientes con antecedentes de carcinoma de próstata, tratados con intención curativa y que presentaban sospecha de recidiva bioquímica con valores bajos de PSA (<3 ng/mL). Los estudios de imagen, ecografía prostática, TC y/o RM pélvica eran negativos, y todos ellos tenían un PET/TC 18F-Colina negativo o no concluyente. Se derivó a todos los pacientes para realizarse un 68 Ga-PSMA-11PET/TC. Protocolo: Dosis 2.2 M Bq/Kg. 20 mg de furosemida en el minuto 0. Imágenes PET/TC desde calota craneal hasta tercio proximal de muslos a los 60 min, e imágenes tardías a las 3 horas si precisara.
: En 9 de los 14 pacientes (64.2%) el 68 Ga-PSMA-11PET/TC consiguió localizar la recidiva bioquímica oculta, y en todos ellos hubo cambios en la actitud terapéutica. En 4 de los 14 pacientes (28.5%) el 68 Ga-PSMA-11PET/TC resultó negativo o no concluyente, se prosiguió con la actitud vigilante con controles de PSA y estudios de imagen según los protocolos habituales. Estos pacientes presentaban los valores más bajos de PSA (inferiores a 1 ng/mL). Uno de los estudios 68 Ga-PSMA-11PET/TC fue no concluyente, informándose la presencia de una dudosa adenopatía iliaca derecha.
El 68 Ga-PSMA-11PET/TC permite un diagnóstico precoz, con valores bajos de PSA, de la recidiva bioquímica oculta del carcinoma de próstata, incluso en pacientes con 18F-Colina PET/TC negativos.</abstract><pub>Elsevier España, S.L.U</pub><doi>10.1016/j.acuroe.2021.04.008</doi><tpages>6</tpages></addata></record> |
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| ispartof | Actas urológicas españolas (English ed.), 2021-06, Vol.45 (5), p.353-358 |
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| source | ScienceDirect Freedom Collection |
| subjects | PET/CT PET/TC Prostate cancer PSMA |
| title | 68Ga-PSMA-11 PET/CT in patients with occult biochemical recurrence of prostate carcinoma and negative 18F-Choline PET/CT. Preliminary assessment of its clinical use |
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