Uncurtaining the pivotal role of ABC transporters in diabetes mellitus

The metabolic disorders are the edge points for the initiation of various diseases. These disorders comprised of several diseases including diabetes, obesity, and cardiovascular complications. Worldwide, the prevalence of these disorders is increasing day by day. The world’s population is at higher...

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Bibliographic Details
Published in:Environmental science and pollution research international 2021-08, Vol.28 (31), p.41533-41551
Main Authors: Behl, Tapan, Sehgal, Aayush, Grover, Madhuri, Singh, Sukhbir, Sharma, Neelam, Bhatia, Saurabh, Al-Harrasi, Ahmed, Aleya, Lotfi, Bungau, Simona
Format: Article
Language:English
Subjects:
AKT protein
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
ATP-Binding Cassette Transporters - genetics
ATP-binding protein
Diabetes
Diabetes Mellitus
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Glucose
Glucose metabolism
Humans
Insulin
Insulin Resistance
Insulin secretion
Insulin-like growth factors
Lipid metabolism
Lipids
MAP kinase
Metabolic disorders
Metabolism
Protein kinase C
Review Article
Signaling
Therapeutic targets
Waste Water Technology
Water Management
Water Pollution Control
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Summary:The metabolic disorders are the edge points for the initiation of various diseases. These disorders comprised of several diseases including diabetes, obesity, and cardiovascular complications. Worldwide, the prevalence of these disorders is increasing day by day. The world’s population is at higher threat of developing metabolic disease, especially diabetes. Therefore, there is an impregnable necessity of searching for a newer therapeutic target to reduce the burden of these disorders. Diabetes mellitus (DM) is marked with the dysregulated insulin secretion and resistance. The lipid and glucose transporters portray a pivotal role in the metabolism and transport of both of these. The excess production of lipid and glucose and decreased clearance of these leads to the emergence of DM. The ATP-binding cassette transporters (ABCT) are important for the metabolism of glucose and lipid. Various studies suggest the key involvement of ABCT in the pathologic process of different diseases. In addition, the involvement of other pathways, including IGF signaling, P13-Akt/PKC/MAPK signaling, and GLP-1 via regulation of ABCT, may help develop new treatment strategies to cope with insulin resistance dysregulated glucose metabolism, key features in DM. Graphical abstract
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-021-14675-y