Effects of aging on basement membrane-related gene expression of the skeletal muscle in rats

The basement membrane (BM), with collagen IV as a major component, plays an important role in the maintenance of muscle structure and its robustness. To investigate the effects of aging on factors related to BM construction, we compared the expression status of these factors in 3- and 20-month-old m...

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Bibliographic Details
Published in:Biomedical Research 2021/06/07, Vol.42(3), pp.115-119
Main Authors: KANAZAWA, Yuji, NAGANO, Mamoru, KOINUMA, Satoshi, SUGIYO, Shinichi, SHIGEYOSHI, Yasufumi
Format: Article
Language:English
Subjects:
Aging
Animals
Basement Membrane - metabolism
Basement membranes
Basements
Body Weight
Bone Marrow - metabolism
Collagen
Collagen (type IV)
Collagen Type IV - biosynthesis
Gene Expression
Gene Expression Profiling
Gene Expression Regulation
Male
Membranes
Muscle, Skeletal - metabolism
Muscles
Osteonectin
Rats
Rats, Wistar
Regeneration
Rodents
Skeletal muscle
Time Factors
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Summary:The basement membrane (BM), with collagen IV as a major component, plays an important role in the maintenance of muscle structure and its robustness. To investigate the effects of aging on factors related to BM construction, we compared the expression status of these factors in 3- and 20-month-old male Wistar rats. The expression levels of Col4a1 and Col4a2 (encoding collagen IV), Sparc (involved in collagen IV functionalization), and Mmp14 (a collagen IV degradation factor) were decreased. These results suggest that aging suppresses collagen IV synthetic and degradative factors and affects BM-related factors in the steady state.
ISSN:0388-6107
1880-313X
DOI:10.2220/biomedres.42.115