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Oxytocin receptor gene polymorphism and low serum oxytocin level are associated with hyperphagia and obesity in adolescents
Background/Objectives In recent years, oxytocin (OXT) and polymorphisms in the oxytocin receptor ( OXTR) gene have been reported to play roles in obesity pathogenesis. However, there was no study evaluating OXTR gene variants in childhood obesity. The aim of the study was to investigate the relation...
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| Published in: | International Journal of Obesity 2021-09, Vol.45 (9), p.2064-2073 |
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| container_end_page | 2073 |
| container_issue | 9 |
| container_start_page | 2064 |
| container_title | International Journal of Obesity |
| container_volume | 45 |
| creator | Çatli, Gönül Acar, Sezer Cingöz, Gülten Rasulova, Khayala Yarim, Ayça Kanat Uzun, Hamide Küme, Tuncay Kızıldağ, Sefa Dündar, Bumin Nuri Abacı, Ayhan |
| description | Background/Objectives
In recent years, oxytocin (OXT) and polymorphisms in the oxytocin receptor (
OXTR)
gene have been reported to play roles in obesity pathogenesis. However, there was no study evaluating
OXTR
gene variants in childhood obesity. The aim of the study was to investigate the relation of
OXTR
gene polymorphisms and serum OXT levels with metabolic and anthropometric parameters in obese and healthy adolescents.
Subjects/Methods
The study was a multi-centered case-control study, which was conducted on obese and healthy adolescents aged between 12 and 17 years. Serum OXT and leptin levels were measured, and
OXTR
gene variants were studied by qPCR (rs53576) and RFLP (rs2254298) methods.
Results
A total of 250 obese and 250 healthy adolescents were included in this study. In the obese group, serum OXT level was lower and leptin level was higher than the control group. In the obese group, frequencies of homozygous mutant (G/G) and heterozygous (A/G) genotypes for rs53576 polymorphism were higher than the control group. Homozygous mutant(G/G) and heterozygous (A/G) genotypes for rs53576 polymorphism were found to increase the risk of obesity compared to the wild type (A/A) genotype [OR = 6.05 and OR = 3.06;
p
|
| doi_str_mv | 10.1038/s41366-021-00876-5 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2538044744</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A672898309</galeid><sourcerecordid>A672898309</sourcerecordid><originalsourceid>FETCH-LOGICAL-c473t-dce117c9b1e4c53158f03372fe16c28fa97f1a29a7ffee3c382f3f584a59b6253</originalsourceid><addsrcrecordid>eNp9kkFrFTEUhQdR7LP6B1xIQJBupiaTZDKzLEWrUOhG1yEvc_MmJZOMScY6-OfN62utFZEsEm6-c7j3cqrqNcGnBNPufWKEtm2NG1Jj3Im25k-qDWH7B-vF02qDKRY15i0_ql6kdI0x5hw3z6sjynBPeE831c-rH2sO2noUQcOcQ0Q78IDm4NYpxHm0aULKD8iFG5QgLhMK9woH38EhFQGplEpFZRjQjc0jGtcZilbtrLoVhy0km1dURGoIDpIGn9PL6plRLsGru_u4-vrxw5fzT_Xl1cXn87PLWjNBcz1oIETofkuAaU4J7wymVDQGSKubzqheGKKaXgljAKimXWOo4R1TvN-2DafH1cnBd47h2wIpy8mWDpxTHsKSZEE6zJhgrKBv_0KvwxJ96a5QLaVt2V_7QO2UA2m9CTkqvTeVZ61our6juC_U6T-ocgaYrA4ejC31R4J3fwhGUC6PKbgl2-DTY7A5gDqGlCIYOUc7qbhKguU-GvIQDVmiIW-jIfdbeHM32rKdYPgtuc9CAegBSOXL7yA-zP4f21_FtMP6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2563365026</pqid></control><display><type>article</type><title>Oxytocin receptor gene polymorphism and low serum oxytocin level are associated with hyperphagia and obesity in adolescents</title><source>Springer Nature</source><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Çatli, Gönül ; Acar, Sezer ; Cingöz, Gülten ; Rasulova, Khayala ; Yarim, Ayça Kanat ; Uzun, Hamide ; Küme, Tuncay ; Kızıldağ, Sefa ; Dündar, Bumin Nuri ; Abacı, Ayhan</creator><creatorcontrib>Çatli, Gönül ; Acar, Sezer ; Cingöz, Gülten ; Rasulova, Khayala ; Yarim, Ayça Kanat ; Uzun, Hamide ; Küme, Tuncay ; Kızıldağ, Sefa ; Dündar, Bumin Nuri ; Abacı, Ayhan</creatorcontrib><description>Background/Objectives
In recent years, oxytocin (OXT) and polymorphisms in the oxytocin receptor (
OXTR)
gene have been reported to play roles in obesity pathogenesis. However, there was no study evaluating
OXTR
gene variants in childhood obesity. The aim of the study was to investigate the relation of
OXTR
gene polymorphisms and serum OXT levels with metabolic and anthropometric parameters in obese and healthy adolescents.
Subjects/Methods
The study was a multi-centered case-control study, which was conducted on obese and healthy adolescents aged between 12 and 17 years. Serum OXT and leptin levels were measured, and
OXTR
gene variants were studied by qPCR (rs53576) and RFLP (rs2254298) methods.
Results
A total of 250 obese and 250 healthy adolescents were included in this study. In the obese group, serum OXT level was lower and leptin level was higher than the control group. In the obese group, frequencies of homozygous mutant (G/G) and heterozygous (A/G) genotypes for rs53576 polymorphism were higher than the control group. Homozygous mutant(G/G) and heterozygous (A/G) genotypes for rs53576 polymorphism were found to increase the risk of obesity compared to the wild type (A/A) genotype [OR = 6.05 and OR = 3.06;
p
< 0.001, respectively]. In patients with homozygous mutant (G/G) and heterozygous (A/G) genotype for rs53576 polymorphism, serum OXT levels were lower than the wild type (A/A) genotype. In the obese group, hyperphagia score was higher than the control group and correlated negatively with serum OXT level.
Conclusions
This study revealed that low serum OXT level, which is associated with hyperphagia may be an underlying cause for obesity in adolescents. For rs53576 polymorphism of the
OXTR
gene, obesity risk is higher in patients with homozygous mutant(G/G) and heterozygous(A/G)genotypes.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/s41366-021-00876-5</identifier><identifier>PMID: 34091593</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/77 ; 692/163/2743/393 ; 692/308 ; Adolescent ; Adolescents ; Case-Control Studies ; Children ; Epidemiology ; Female ; Gene polymorphism ; Genetic aspects ; Genetic polymorphisms ; Genotype & phenotype ; Genotypes ; Health aspects ; Health Promotion and Disease Prevention ; Hormone receptors ; Humans ; Hyperphagia ; Hyperphagia - blood ; Hyperphagia - complications ; Internal Medicine ; Leptin ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Mutants ; Obesity ; Obesity in adolescence ; Oxytocin ; Oxytocin - analysis ; Oxytocin - blood ; Pathogenesis ; Pediatric Obesity - blood ; Pediatric Obesity - complications ; Pediatric research ; Polymorphism ; Polymorphism, Genetic ; Public Health ; Receptors ; Receptors, Oxytocin - genetics ; Risk factors ; Teenagers</subject><ispartof>International Journal of Obesity, 2021-09, Vol.45 (9), p.2064-2073</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature Limited.</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-dce117c9b1e4c53158f03372fe16c28fa97f1a29a7ffee3c382f3f584a59b6253</citedby><cites>FETCH-LOGICAL-c473t-dce117c9b1e4c53158f03372fe16c28fa97f1a29a7ffee3c382f3f584a59b6253</cites><orcidid>0000-0002-0488-6377 ; 0000-0002-3002-480X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34091593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Çatli, Gönül</creatorcontrib><creatorcontrib>Acar, Sezer</creatorcontrib><creatorcontrib>Cingöz, Gülten</creatorcontrib><creatorcontrib>Rasulova, Khayala</creatorcontrib><creatorcontrib>Yarim, Ayça Kanat</creatorcontrib><creatorcontrib>Uzun, Hamide</creatorcontrib><creatorcontrib>Küme, Tuncay</creatorcontrib><creatorcontrib>Kızıldağ, Sefa</creatorcontrib><creatorcontrib>Dündar, Bumin Nuri</creatorcontrib><creatorcontrib>Abacı, Ayhan</creatorcontrib><title>Oxytocin receptor gene polymorphism and low serum oxytocin level are associated with hyperphagia and obesity in adolescents</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background/Objectives
In recent years, oxytocin (OXT) and polymorphisms in the oxytocin receptor (
OXTR)
gene have been reported to play roles in obesity pathogenesis. However, there was no study evaluating
OXTR
gene variants in childhood obesity. The aim of the study was to investigate the relation of
OXTR
gene polymorphisms and serum OXT levels with metabolic and anthropometric parameters in obese and healthy adolescents.
Subjects/Methods
The study was a multi-centered case-control study, which was conducted on obese and healthy adolescents aged between 12 and 17 years. Serum OXT and leptin levels were measured, and
OXTR
gene variants were studied by qPCR (rs53576) and RFLP (rs2254298) methods.
Results
A total of 250 obese and 250 healthy adolescents were included in this study. In the obese group, serum OXT level was lower and leptin level was higher than the control group. In the obese group, frequencies of homozygous mutant (G/G) and heterozygous (A/G) genotypes for rs53576 polymorphism were higher than the control group. Homozygous mutant(G/G) and heterozygous (A/G) genotypes for rs53576 polymorphism were found to increase the risk of obesity compared to the wild type (A/A) genotype [OR = 6.05 and OR = 3.06;
p
< 0.001, respectively]. In patients with homozygous mutant (G/G) and heterozygous (A/G) genotype for rs53576 polymorphism, serum OXT levels were lower than the wild type (A/A) genotype. In the obese group, hyperphagia score was higher than the control group and correlated negatively with serum OXT level.
Conclusions
This study revealed that low serum OXT level, which is associated with hyperphagia may be an underlying cause for obesity in adolescents. For rs53576 polymorphism of the
OXTR
gene, obesity risk is higher in patients with homozygous mutant(G/G) and heterozygous(A/G)genotypes.</description><subject>45/77</subject><subject>692/163/2743/393</subject><subject>692/308</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Case-Control Studies</subject><subject>Children</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Health aspects</subject><subject>Health Promotion and Disease Prevention</subject><subject>Hormone receptors</subject><subject>Humans</subject><subject>Hyperphagia</subject><subject>Hyperphagia - blood</subject><subject>Hyperphagia - complications</subject><subject>Internal Medicine</subject><subject>Leptin</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Mutants</subject><subject>Obesity</subject><subject>Obesity in adolescence</subject><subject>Oxytocin</subject><subject>Oxytocin - analysis</subject><subject>Oxytocin - blood</subject><subject>Pathogenesis</subject><subject>Pediatric Obesity - blood</subject><subject>Pediatric Obesity - complications</subject><subject>Pediatric research</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Public Health</subject><subject>Receptors</subject><subject>Receptors, Oxytocin - genetics</subject><subject>Risk factors</subject><subject>Teenagers</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kkFrFTEUhQdR7LP6B1xIQJBupiaTZDKzLEWrUOhG1yEvc_MmJZOMScY6-OfN62utFZEsEm6-c7j3cqrqNcGnBNPufWKEtm2NG1Jj3Im25k-qDWH7B-vF02qDKRY15i0_ql6kdI0x5hw3z6sjynBPeE831c-rH2sO2noUQcOcQ0Q78IDm4NYpxHm0aULKD8iFG5QgLhMK9woH38EhFQGplEpFZRjQjc0jGtcZilbtrLoVhy0km1dURGoIDpIGn9PL6plRLsGru_u4-vrxw5fzT_Xl1cXn87PLWjNBcz1oIETofkuAaU4J7wymVDQGSKubzqheGKKaXgljAKimXWOo4R1TvN-2DafH1cnBd47h2wIpy8mWDpxTHsKSZEE6zJhgrKBv_0KvwxJ96a5QLaVt2V_7QO2UA2m9CTkqvTeVZ61our6juC_U6T-ocgaYrA4ejC31R4J3fwhGUC6PKbgl2-DTY7A5gDqGlCIYOUc7qbhKguU-GvIQDVmiIW-jIfdbeHM32rKdYPgtuc9CAegBSOXL7yA-zP4f21_FtMP6</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Çatli, Gönül</creator><creator>Acar, Sezer</creator><creator>Cingöz, Gülten</creator><creator>Rasulova, Khayala</creator><creator>Yarim, Ayça Kanat</creator><creator>Uzun, Hamide</creator><creator>Küme, Tuncay</creator><creator>Kızıldağ, Sefa</creator><creator>Dündar, Bumin Nuri</creator><creator>Abacı, Ayhan</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0488-6377</orcidid><orcidid>https://orcid.org/0000-0002-3002-480X</orcidid></search><sort><creationdate>20210901</creationdate><title>Oxytocin receptor gene polymorphism and low serum oxytocin level are associated with hyperphagia and obesity in adolescents</title><author>Çatli, Gönül ; Acar, Sezer ; Cingöz, Gülten ; Rasulova, Khayala ; Yarim, Ayça Kanat ; Uzun, Hamide ; Küme, Tuncay ; Kızıldağ, Sefa ; Dündar, Bumin Nuri ; Abacı, Ayhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-dce117c9b1e4c53158f03372fe16c28fa97f1a29a7ffee3c382f3f584a59b6253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>45/77</topic><topic>692/163/2743/393</topic><topic>692/308</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Case-Control Studies</topic><topic>Children</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Health aspects</topic><topic>Health Promotion and Disease Prevention</topic><topic>Hormone receptors</topic><topic>Humans</topic><topic>Hyperphagia</topic><topic>Hyperphagia - blood</topic><topic>Hyperphagia - complications</topic><topic>Internal Medicine</topic><topic>Leptin</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Mutants</topic><topic>Obesity</topic><topic>Obesity in adolescence</topic><topic>Oxytocin</topic><topic>Oxytocin - analysis</topic><topic>Oxytocin - blood</topic><topic>Pathogenesis</topic><topic>Pediatric Obesity - blood</topic><topic>Pediatric Obesity - complications</topic><topic>Pediatric research</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Public Health</topic><topic>Receptors</topic><topic>Receptors, Oxytocin - genetics</topic><topic>Risk factors</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Çatli, Gönül</creatorcontrib><creatorcontrib>Acar, Sezer</creatorcontrib><creatorcontrib>Cingöz, Gülten</creatorcontrib><creatorcontrib>Rasulova, Khayala</creatorcontrib><creatorcontrib>Yarim, Ayça Kanat</creatorcontrib><creatorcontrib>Uzun, Hamide</creatorcontrib><creatorcontrib>Küme, Tuncay</creatorcontrib><creatorcontrib>Kızıldağ, Sefa</creatorcontrib><creatorcontrib>Dündar, Bumin Nuri</creatorcontrib><creatorcontrib>Abacı, Ayhan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Çatli, Gönül</au><au>Acar, Sezer</au><au>Cingöz, Gülten</au><au>Rasulova, Khayala</au><au>Yarim, Ayça Kanat</au><au>Uzun, Hamide</au><au>Küme, Tuncay</au><au>Kızıldağ, Sefa</au><au>Dündar, Bumin Nuri</au><au>Abacı, Ayhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxytocin receptor gene polymorphism and low serum oxytocin level are associated with hyperphagia and obesity in adolescents</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>45</volume><issue>9</issue><spage>2064</spage><epage>2073</epage><pages>2064-2073</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><abstract>Background/Objectives
In recent years, oxytocin (OXT) and polymorphisms in the oxytocin receptor (
OXTR)
gene have been reported to play roles in obesity pathogenesis. However, there was no study evaluating
OXTR
gene variants in childhood obesity. The aim of the study was to investigate the relation of
OXTR
gene polymorphisms and serum OXT levels with metabolic and anthropometric parameters in obese and healthy adolescents.
Subjects/Methods
The study was a multi-centered case-control study, which was conducted on obese and healthy adolescents aged between 12 and 17 years. Serum OXT and leptin levels were measured, and
OXTR
gene variants were studied by qPCR (rs53576) and RFLP (rs2254298) methods.
Results
A total of 250 obese and 250 healthy adolescents were included in this study. In the obese group, serum OXT level was lower and leptin level was higher than the control group. In the obese group, frequencies of homozygous mutant (G/G) and heterozygous (A/G) genotypes for rs53576 polymorphism were higher than the control group. Homozygous mutant(G/G) and heterozygous (A/G) genotypes for rs53576 polymorphism were found to increase the risk of obesity compared to the wild type (A/A) genotype [OR = 6.05 and OR = 3.06;
p
< 0.001, respectively]. In patients with homozygous mutant (G/G) and heterozygous (A/G) genotype for rs53576 polymorphism, serum OXT levels were lower than the wild type (A/A) genotype. In the obese group, hyperphagia score was higher than the control group and correlated negatively with serum OXT level.
Conclusions
This study revealed that low serum OXT level, which is associated with hyperphagia may be an underlying cause for obesity in adolescents. For rs53576 polymorphism of the
OXTR
gene, obesity risk is higher in patients with homozygous mutant(G/G) and heterozygous(A/G)genotypes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34091593</pmid><doi>10.1038/s41366-021-00876-5</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0488-6377</orcidid><orcidid>https://orcid.org/0000-0002-3002-480X</orcidid></addata></record> |
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| ispartof | International Journal of Obesity, 2021-09, Vol.45 (9), p.2064-2073 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2538044744 |
| source | Springer Nature; Nature; Alma/SFX Local Collection |
| subjects | 45/77 692/163/2743/393 692/308 Adolescent Adolescents Case-Control Studies Children Epidemiology Female Gene polymorphism Genetic aspects Genetic polymorphisms Genotype & phenotype Genotypes Health aspects Health Promotion and Disease Prevention Hormone receptors Humans Hyperphagia Hyperphagia - blood Hyperphagia - complications Internal Medicine Leptin Male Medicine Medicine & Public Health Metabolic Diseases Mutants Obesity Obesity in adolescence Oxytocin Oxytocin - analysis Oxytocin - blood Pathogenesis Pediatric Obesity - blood Pediatric Obesity - complications Pediatric research Polymorphism Polymorphism, Genetic Public Health Receptors Receptors, Oxytocin - genetics Risk factors Teenagers |
| title | Oxytocin receptor gene polymorphism and low serum oxytocin level are associated with hyperphagia and obesity in adolescents |
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