Squamous Cell Carcinoma of the Anal Verge with Sigmoid Colon Metastasis

•The incidence of anal cancer is rising in the United States, and most anal squamous cell carcinoma (SCCA) is associated with high-risk human papillomavirus subtypes.•Not all patients with SCCA have the typical risk factors for development of the disease.•SCCA rarely metastasizes, but most common si...

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Bibliographic Details
Published in:Clinical colorectal cancer 2021-09, Vol.20 (3), p.e210-e213
Main Authors: Livingston, Austin J., Bailey, Christina E., Washington, M. Kay, Eng, Cathy
Format: Article
Language:English
Subjects:
Anal Canal
anal cancer
anal squamous cell
Anus Neoplasms
Carcinoma, Squamous Cell
Colon, Sigmoid - diagnostic imaging
Humans
immunooncology
metastases
pembrolizumab
Rectal Neoplasms
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Summary:•The incidence of anal cancer is rising in the United States, and most anal squamous cell carcinoma (SCCA) is associated with high-risk human papillomavirus subtypes.•Not all patients with SCCA have the typical risk factors for development of the disease.•SCCA rarely metastasizes, but most common sites are liver, lung, extrapelvic lymph nodes, peritoneum, and bone.•This is a case of a patient with SCCA that metastasized to his sigmoid colon without evidence of other distant disease.•Pembrolizumab is an option for patients with advanced SCCA that is not amenable to chemotherapy or surgical resection. It has also been recently approved for tumors with high tumor mutation burden.
ISSN:1533-0028
1938-0674
DOI:10.1016/j.clcc.2021.04.005