Structure and Immunomodulatory Activity of Glycogen Derived from Honeybee Larvae (Apis mellifera)

Honeybee larvae have been recognized as nutrient-rich food in many countries. Although glycogen, a storage form of glucose in animals, is synthesized in honeybee larvae, there is no information on the structure of glycan and its biological activity. In this study, we successfully extracted glycogen...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2021/08/01, Vol.44(8), pp.1156-1159
Main Authors: Nagasaki, Yuto, Abe, Misato, Onishi, Shoichi, Okamoto, Yusuke, Toida, Toshihiko, Higashi, Kyohei
Format: Article
Language:English
Subjects:
Bees
Biological activity
Functional foods & nutraceuticals
Glycogen
honeybee larvae
Immunomodulation
immunomodulatory activity
Larvae
Liver
Molecular weight
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:Honeybee larvae have been recognized as nutrient-rich food in many countries. Although glycogen, a storage form of glucose in animals, is synthesized in honeybee larvae, there is no information on the structure of glycan and its biological activity. In this study, we successfully extracted glycogen from honeybee larvae using hot water extraction and investigated the structure and biological activity of glycan. It was found that the molecular weight of glycogen from honeybee larvae is higher than that of glycogen from bovine liver and oysters. In addition, treatment of RAW264.7 cells with glycogen from honeybee larvae resulted in a much higher production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 than treatment with glycogen from either bovine liver or oysters. These results suggest that the high molecular weight glycogen from honeybee larvae is a functional food ingredient with immunomodulatory activity.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b21-00239