Synthesis of Structurally Diverse Allylsilanes via Copper-Catalyzed Regiodivergent Hydrosilylation of 1,3-Dienes

Unprecedented copper-catalyzed regiodivergent hydrosilylation reactions of substituted 1,3-dienes with hydrosilanes have been developed. The 1,2- and 1,4-hydrosilylations of 1-(hetero)­aryl-substituted 1,3-dienes were highly selectively controlled via variation of the catalytic systems. Meanwhile, t...

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Bibliographic Details
Published in:Organic letters 2021-06, Vol.23 (12), p.4736-4742
Main Authors: Wang, Zi-Lu, Wang, Ying, Xu, Jian-Lin, Zhao, Meng, Dai, Kai-Yang, Shan, Cui-Cui, Xu, Yun-He
Format: Article
Language:English
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Summary:Unprecedented copper-catalyzed regiodivergent hydrosilylation reactions of substituted 1,3-dienes with hydrosilanes have been developed. The 1,2- and 1,4-hydrosilylations of 1-(hetero)­aryl-substituted 1,3-dienes were highly selectively controlled via variation of the catalytic systems. Meanwhile, the 1,4-hydrosilylation reaction of 2-aryl-substituted 1,3-dienes with diphenylsilane was also successfully realized for the first time. These methods provide convenient and efficient approaches for the synthesis of structurally diverse allylsilanes.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c01455