The prevalence and functional characteristics of CrpP-like in Pseudomonas aeruginosa isolates from China

Modifying enzyme-CrpP and its variants reduced the MICs of fluoroquinolones in Pseudomonas aeruginosa . This study investigated the dissemination and functional characteristics of CrpP-like in P. aeruginosa from China. The positive rate of crpP -like genes in 228 P. aeruginosa was 25.4% (58/228), an...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2021-12, Vol.40 (12), p.2651-2656
Main Authors: Xu, Ye, Zhang, Ying, Zheng, Xiangkuo, Yu, Kaihang, Sun, Yao, Liao, Wenli, Jia, Huaiyu, Xu, Chunquan, Zhou, Tieli, Shen, Mo
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibiotics
Antimicrobial agents
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Biomedical and Life Sciences
Biomedicine
Brief Report
China
Ciprofloxacin - pharmacology
Enzymes
Experiments
Fluoroquinolones
Genes
Genetic diversity
Genetic transformation
Hospitals
Humans
Infectious diseases
Internal Medicine
Laboratories
Medical Microbiology
Microbial Sensitivity Tests
Mutation
Plasmids
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - enzymology
Pseudomonas aeruginosa - genetics
Pseudomonas aeruginosa - isolation & purification
Pseudomonas Infections - microbiology
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Summary:Modifying enzyme-CrpP and its variants reduced the MICs of fluoroquinolones in Pseudomonas aeruginosa . This study investigated the dissemination and functional characteristics of CrpP-like in P. aeruginosa from China. The positive rate of crpP -like genes in 228 P. aeruginosa was 25.4% (58/228), and 6 new crpP -like genes were determined. Transformation experiments showed that CrpP-like had a low effect on CIP and LEV susceptibility. The genetic of crpP -positive was diverse. Furthermore, the mean expression level of crpP was no statistical difference between fluoroquinolone-susceptible and -resistant group ( P  > 0.05). CrpP-like may not play a significant role in fluoroquinolone resistance in P. aeruginosa .
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-021-04287-2