In vivo-wound healing studies of sodium thiosulfate gel in rats

Sodium Thiosulfate (STS) is already reported as an antioxidant, anti-inflammatory agent with antiseptic, antifungal properties. The search for an ideal antiseptic still continues, which is lethal to all types of bacteria and their spores and sustain the activity for a longer time without any harm to...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2021-08, Vol.140, p.111797-111797, Article 111797
Main Authors: Grover, Priyanka, Khanna, Kushagra, Bhatnagar, Aseem, Purkayastha, Jubilee
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents, Local - therapeutic use
Antiinflammatoy
Antioxidant activities
Catalase - metabolism
Gels
Glutathione Peroxidase - metabolism
Interleukin-10 - metabolism
Male
Povidone-Iodine - therapeutic use
Rats
Rats, Sprague-Dawley
Skin - drug effects
Skin - metabolism
Skin - pathology
STS
Superoxide Dismutase - metabolism
Thiosulfates - therapeutic use
Tumor Necrosis Factor-alpha - metabolism
Wound healing
Wound Healing - drug effects
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Summary:Sodium Thiosulfate (STS) is already reported as an antioxidant, anti-inflammatory agent with antiseptic, antifungal properties. The search for an ideal antiseptic still continues, which is lethal to all types of bacteria and their spores and sustain the activity for a longer time without any harm to the host tissue. The aim of the present study is to evaluate the effect of STS on curing of wounds in rats when compared to Betadine. We developed topical gels having 6% and 12% STS. The effects of STS on wound healing rate of Rats were evaluated against Betadine as positive control. Wounds of control group, selected as Group 1 was treated with normal saline (0.2 ml), twice a day. Reference standard control, designated as Group 2 rats were given with 0.2 ml Betadine twice a day. Rats in Groups 3 and 4 were treated with 0.2 ml of STS gel (6% or 12% respectively) twice a day. In our study, STS formulation has proved to be a safe and efficient wound healing product. It has a neutral pH and longer half life (>12 months). Higher STS dose of 12% proved to have a wound curing rate equivalent to that of Betadine. On 11th Day, 97 ± 0.79% healing was achieved with Betadine and 98 ± 0.67% with 12% STS Gel (∗P 12 months).•H&E stained skin tissue showed efficient wound healing with 12% STS formulation.•Enhancement was in the levels of GPx, CAT, SOD, IL 10 at wound tissue. TNF-α levels decreased.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2021.111797