Clinical relevance of nitrated beta 2-glycoprotein I in antiphospholipid syndrome: Implications for thrombosis risk

• Published in: Journal of autoimmunity 2021-08, Vol.122, p.102675-102675, Article 102675
• Main Authors: Krilis, M., Qi, M., Ioannou, Y., Zhang, J.Y., Ahmadi, Z., Wong, J.W.H., Vlachoyiannopoulos, P.G., Moutsopoulos, H.M., Koike, T., Sturgess, A.D., Chong, B.H., Krilis, S.A., Giannakopoulos, B.
• Format: Article
• Language: English
• Subjects: Antiphospholipid syndrome; Antiphospholipid Syndrome - blood; Antiphospholipid Syndrome - complications; Antiphospholipid Syndrome - immunology; beta 2-Glycoprotein I - blood; beta 2-Glycoprotein I - immunology; beta 2-Glycoprotein I - metabolism; Case-Control Studies; Healthy Volunteers; Humans; Lipid Peroxidation; Nitrates - metabolism; Nitration; Nitrosative stress; Platelet Aggregation - immunology; Post-translational modification; Protein Processing, Post-Translational - immunology; Risk Factors; Thrombosis; Thrombosis - blood; Thrombosis - immunology; βeta-2-glycoprotein I
• ISSN: 0896-8411; 1095-9157
• DOI: 10.1016/j.jaut.2021.102675

Β2-Glycoprotein I (β2GPI) is an important anti-thrombotic protein and is the major auto-antigen in the antiphospholipid syndrome (APS). The clinical relevance of nitrosative stress in post translational modification of β2GPI was examined.The effects of nitrated (n)β2GPI on its anti-thrombotic properties and its plasma levels in primary and secondary APS were determined with appropriate clinical control groups. β2-glycoprotein I was nitrated at tyrosines 218, 275 and 309. β2-glycoprotein I binds to lipid peroxidation modified products through Domains IV and V. Nitrated β2GPI loses this binding (p