Mild gray matter atrophy in patients with long-standing multiple sclerosis and favorable clinical course

The mechanisms responsible for the favorable clinical course in multiple sclerosis (MS) remain unclear. In this longitudinal study, we assessed whether magnetic resonance imaging (MRI)-based changes in focal and diffuse brain damage are associated with a long-term favorable MS diseases course. We fo...

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Bibliographic Details
Published in:Multiple sclerosis 2022-01, Vol.28 (1), p.154-159
Main Authors: Cortese, Rosa, Battaglini, Marco, Parodi, Francesca, Stromillo, Maria Laura, Portaccio, Emilio, Razzolini, Lorenzo, Giorgio, Antonio, Sormani, Maria Pia, Amato, Maria Pia, De Stefano, Nicola
Format: Article
Language:English
Subjects:
Atrophy
Atrophy - pathology
Brain - diagnostic imaging
Brain - pathology
Brain injury
Gray Matter - diagnostic imaging
Gray Matter - pathology
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Multiple sclerosis
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - pathology
Neuroimaging
Patients
Substantia grisea
White Matter - pathology
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Summary:The mechanisms responsible for the favorable clinical course in multiple sclerosis (MS) remain unclear. In this longitudinal study, we assessed whether magnetic resonance imaging (MRI)-based changes in focal and diffuse brain damage are associated with a long-term favorable MS diseases course. We found that global brain and gray matter (GM) atrophy changes were milder in MS patients with long-standing disease (⩾30 years from onset) and favorable (no/minimal disability) clinical course than in sex-age-matched disable MS patients, independently of lesions accumulation. Data showed that different trajectories of volume changes, as reflected by mild GM atrophy, may characterize patients with long-term favorable evolution.
ISSN:1352-4585
1477-0970
DOI:10.1177/13524585211019650