Serotonin 2A receptor function and depression-like behavior in rats model of hypothyroidism

Hypothyroidism causes somatic, psychosocial and affective psychosis, including depression-like behaviors. In this study, (hypothyroidism group; HP group) adult male Sprague Dawley (SD) rats were induced to hypothyroidism after 5 weeks of exposure to 0.05% propylthiouracil (PTU) in potable water, con...

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Bibliographic Details
Published in:Experimental brain research 2021-08, Vol.239 (8), p.2435-2444
Main Authors: Jin, Zhicheng, Ling, Jianer, Yu, Jing, He, Mengzi, Ni, Pingping, Zhang, Fang, Wang, Yizhen
Format: Article
Language:English
Subjects:
Behavior
Biomedical and Life Sciences
Biomedicine
Complications and side effects
Depression, Mental
Development and progression
Drinking water
Emotional behavior
Hypothyroidism
Mental depression
Neurology
Neurosciences
Open-field behavior
Prefrontal cortex
Propylthiouracil
Psychological aspects
Psychosis
Receptors
Research Article
Serotonin
Serotonin S2 receptors
Water content
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Summary:Hypothyroidism causes somatic, psychosocial and affective psychosis, including depression-like behaviors. In this study, (hypothyroidism group; HP group) adult male Sprague Dawley (SD) rats were induced to hypothyroidism after 5 weeks of exposure to 0.05% propylthiouracil (PTU) in potable water, control animals (CON group) were given the same amount of water. The following behavioral experiments were conducted, respectively: open-field test (OFT), forced swimming test (FST), tail suspension test (TST). TT 3 and TT 4 levels were measured after the behavior tests and the expression levels of 5-HT 2 A receptor and 5-HT 2 A receptor proteins were analyzed in the hippocampus and prefrontal cortex. The level of TT 3 and TT 4 in the HP group rats was much lower than that in the CON group. The hypothyroid rats also showed weight loss, much longer immobility time in tail suspension test and forced swimming test. Besides, 5 weeks of PTU administration was associated with significantly decreased expression levels of 5-HT 2 A receptor and 5-HT 2 A receptor proteins compared with control group, which were significantly negatively correlated with immobility time in FST and TST. In conclusion, our results suggest that hypothyroidism induces depressive behaviors through the influence of the serotonin system, and the decreased expression of the 5-HT 2 A receptor is an important cause of the depressive behaviors in hypothyroidism.
ISSN:0014-4819
1432-1106
DOI:10.1007/s00221-021-06129-1