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Serotonin 2A receptor function and depression-like behavior in rats model of hypothyroidism
Hypothyroidism causes somatic, psychosocial and affective psychosis, including depression-like behaviors. In this study, (hypothyroidism group; HP group) adult male Sprague Dawley (SD) rats were induced to hypothyroidism after 5 weeks of exposure to 0.05% propylthiouracil (PTU) in potable water, con...
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| Published in: | Experimental brain research 2021-08, Vol.239 (8), p.2435-2444 |
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| creator | Jin, Zhicheng Ling, Jianer Yu, Jing He, Mengzi Ni, Pingping Zhang, Fang Wang, Yizhen |
| description | Hypothyroidism causes somatic, psychosocial and affective psychosis, including depression-like behaviors. In this study, (hypothyroidism group; HP group) adult male Sprague Dawley (SD) rats were induced to hypothyroidism after 5 weeks of exposure to 0.05% propylthiouracil (PTU) in potable water, control animals (CON group) were given the same amount of water. The following behavioral experiments were conducted, respectively: open-field test (OFT), forced swimming test (FST), tail suspension test (TST). TT
3
and TT
4
levels were measured after the behavior tests and the expression levels of 5-HT
2
A
receptor and 5-HT
2
A
receptor proteins were analyzed in the hippocampus and prefrontal cortex. The level of TT
3
and TT
4
in the HP group rats was much lower than that in the CON group. The hypothyroid rats also showed weight loss, much longer immobility time in tail suspension test and forced swimming test. Besides, 5 weeks of PTU administration was associated with significantly decreased expression levels of 5-HT
2
A
receptor and 5-HT
2
A
receptor proteins compared with control group, which were significantly negatively correlated with immobility time in FST and TST. In conclusion, our results suggest that hypothyroidism induces depressive behaviors through the influence of the serotonin system, and the decreased expression of the 5-HT
2
A
receptor is an important cause of the depressive behaviors in hypothyroidism. |
| doi_str_mv | 10.1007/s00221-021-06129-1 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2539524513</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A671531246</galeid><sourcerecordid>A671531246</sourcerecordid><originalsourceid>FETCH-LOGICAL-c484t-6b07e25139a19fd897b32a0d5fb3ff9b193fd386ce773ba9e85a6b94eec798613</originalsourceid><addsrcrecordid>eNp9kl2L1TAQhoMoeFz9A14FBNGLrvlo2ubysPixsCC4euVFSNPJadY2qUkqnn9vyhHWIyJhCDM87yTMvAg9p-SSEtK-SYQwRiuyRUOZrOgDtKM1ZxWlpHmIdoTQuqo7Kh-jJyndbSlvyQ59vYUYcvDOY7bHEQwsOURsV2-yCx5rP-ABlggplbSa3DfAPYz6hytUEUWdE57DABMOFo_HJeTxGIMbXJqfokdWTwme_b4v0Jd3bz9ffahuPr6_vtrfVKbu6lw1PWmBCcqlptIOnWx7zjQZhO25tbKnktuBd42BtuW9ltAJ3fSyBjCt7BrKL9CrU98lhu8rpKxmlwxMk_YQ1qSY4FKwurxQ0Bd_oXdhjb78rlBCSkFaIu6pg55AOW9DjtpsTdW-aanglNVNoS7_QZUzwOxM8GBdqZ8JXp8JCpPhZz7oNSV1ffvpnH35BzuCnvKYwrRuS0nnIDuBJoaUIli1RDfreFSUqM0b6uQNRbbYvKG2ifGTKBXYHyDej-E_ql-YTrjo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2559950705</pqid></control><display><type>article</type><title>Serotonin 2A receptor function and depression-like behavior in rats model of hypothyroidism</title><source>Social Science Premium Collection</source><source>Springer Nature</source><creator>Jin, Zhicheng ; Ling, Jianer ; Yu, Jing ; He, Mengzi ; Ni, Pingping ; Zhang, Fang ; Wang, Yizhen</creator><creatorcontrib>Jin, Zhicheng ; Ling, Jianer ; Yu, Jing ; He, Mengzi ; Ni, Pingping ; Zhang, Fang ; Wang, Yizhen</creatorcontrib><description>Hypothyroidism causes somatic, psychosocial and affective psychosis, including depression-like behaviors. In this study, (hypothyroidism group; HP group) adult male Sprague Dawley (SD) rats were induced to hypothyroidism after 5 weeks of exposure to 0.05% propylthiouracil (PTU) in potable water, control animals (CON group) were given the same amount of water. The following behavioral experiments were conducted, respectively: open-field test (OFT), forced swimming test (FST), tail suspension test (TST). TT
3
and TT
4
levels were measured after the behavior tests and the expression levels of 5-HT
2
A
receptor and 5-HT
2
A
receptor proteins were analyzed in the hippocampus and prefrontal cortex. The level of TT
3
and TT
4
in the HP group rats was much lower than that in the CON group. The hypothyroid rats also showed weight loss, much longer immobility time in tail suspension test and forced swimming test. Besides, 5 weeks of PTU administration was associated with significantly decreased expression levels of 5-HT
2
A
receptor and 5-HT
2
A
receptor proteins compared with control group, which were significantly negatively correlated with immobility time in FST and TST. In conclusion, our results suggest that hypothyroidism induces depressive behaviors through the influence of the serotonin system, and the decreased expression of the 5-HT
2
A
receptor is an important cause of the depressive behaviors in hypothyroidism.</description><identifier>ISSN: 0014-4819</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/s00221-021-06129-1</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Behavior ; Biomedical and Life Sciences ; Biomedicine ; Complications and side effects ; Depression, Mental ; Development and progression ; Drinking water ; Emotional behavior ; Hypothyroidism ; Mental depression ; Neurology ; Neurosciences ; Open-field behavior ; Prefrontal cortex ; Propylthiouracil ; Psychological aspects ; Psychosis ; Receptors ; Research Article ; Serotonin ; Serotonin S2 receptors ; Water content</subject><ispartof>Experimental brain research, 2021-08, Vol.239 (8), p.2435-2444</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-6b07e25139a19fd897b32a0d5fb3ff9b193fd386ce773ba9e85a6b94eec798613</citedby><cites>FETCH-LOGICAL-c484t-6b07e25139a19fd897b32a0d5fb3ff9b193fd386ce773ba9e85a6b94eec798613</cites><orcidid>0000-0002-3208-0821</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2559950705/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2559950705?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21394,27924,27925,33611,33612,43733,74221</link.rule.ids></links><search><creatorcontrib>Jin, Zhicheng</creatorcontrib><creatorcontrib>Ling, Jianer</creatorcontrib><creatorcontrib>Yu, Jing</creatorcontrib><creatorcontrib>He, Mengzi</creatorcontrib><creatorcontrib>Ni, Pingping</creatorcontrib><creatorcontrib>Zhang, Fang</creatorcontrib><creatorcontrib>Wang, Yizhen</creatorcontrib><title>Serotonin 2A receptor function and depression-like behavior in rats model of hypothyroidism</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><description>Hypothyroidism causes somatic, psychosocial and affective psychosis, including depression-like behaviors. In this study, (hypothyroidism group; HP group) adult male Sprague Dawley (SD) rats were induced to hypothyroidism after 5 weeks of exposure to 0.05% propylthiouracil (PTU) in potable water, control animals (CON group) were given the same amount of water. The following behavioral experiments were conducted, respectively: open-field test (OFT), forced swimming test (FST), tail suspension test (TST). TT
3
and TT
4
levels were measured after the behavior tests and the expression levels of 5-HT
2
A
receptor and 5-HT
2
A
receptor proteins were analyzed in the hippocampus and prefrontal cortex. The level of TT
3
and TT
4
in the HP group rats was much lower than that in the CON group. The hypothyroid rats also showed weight loss, much longer immobility time in tail suspension test and forced swimming test. Besides, 5 weeks of PTU administration was associated with significantly decreased expression levels of 5-HT
2
A
receptor and 5-HT
2
A
receptor proteins compared with control group, which were significantly negatively correlated with immobility time in FST and TST. In conclusion, our results suggest that hypothyroidism induces depressive behaviors through the influence of the serotonin system, and the decreased expression of the 5-HT
2
A
receptor is an important cause of the depressive behaviors in hypothyroidism.</description><subject>Behavior</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Complications and side effects</subject><subject>Depression, Mental</subject><subject>Development and progression</subject><subject>Drinking water</subject><subject>Emotional behavior</subject><subject>Hypothyroidism</subject><subject>Mental depression</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Open-field behavior</subject><subject>Prefrontal cortex</subject><subject>Propylthiouracil</subject><subject>Psychological aspects</subject><subject>Psychosis</subject><subject>Receptors</subject><subject>Research Article</subject><subject>Serotonin</subject><subject>Serotonin S2 receptors</subject><subject>Water content</subject><issn>0014-4819</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>M2R</sourceid><recordid>eNp9kl2L1TAQhoMoeFz9A14FBNGLrvlo2ubysPixsCC4euVFSNPJadY2qUkqnn9vyhHWIyJhCDM87yTMvAg9p-SSEtK-SYQwRiuyRUOZrOgDtKM1ZxWlpHmIdoTQuqo7Kh-jJyndbSlvyQ59vYUYcvDOY7bHEQwsOURsV2-yCx5rP-ABlggplbSa3DfAPYz6hytUEUWdE57DABMOFo_HJeTxGIMbXJqfokdWTwme_b4v0Jd3bz9ffahuPr6_vtrfVKbu6lw1PWmBCcqlptIOnWx7zjQZhO25tbKnktuBd42BtuW9ltAJ3fSyBjCt7BrKL9CrU98lhu8rpKxmlwxMk_YQ1qSY4FKwurxQ0Bd_oXdhjb78rlBCSkFaIu6pg55AOW9DjtpsTdW-aanglNVNoS7_QZUzwOxM8GBdqZ8JXp8JCpPhZz7oNSV1ffvpnH35BzuCnvKYwrRuS0nnIDuBJoaUIli1RDfreFSUqM0b6uQNRbbYvKG2ifGTKBXYHyDej-E_ql-YTrjo</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Jin, Zhicheng</creator><creator>Ling, Jianer</creator><creator>Yu, Jing</creator><creator>He, Mengzi</creator><creator>Ni, Pingping</creator><creator>Zhang, Fang</creator><creator>Wang, Yizhen</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>0-V</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3208-0821</orcidid></search><sort><creationdate>20210801</creationdate><title>Serotonin 2A receptor function and depression-like behavior in rats model of hypothyroidism</title><author>Jin, Zhicheng ; Ling, Jianer ; Yu, Jing ; He, Mengzi ; Ni, Pingping ; Zhang, Fang ; Wang, Yizhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-6b07e25139a19fd897b32a0d5fb3ff9b193fd386ce773ba9e85a6b94eec798613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Behavior</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Complications and side effects</topic><topic>Depression, Mental</topic><topic>Development and progression</topic><topic>Drinking water</topic><topic>Emotional behavior</topic><topic>Hypothyroidism</topic><topic>Mental depression</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Open-field behavior</topic><topic>Prefrontal cortex</topic><topic>Propylthiouracil</topic><topic>Psychological aspects</topic><topic>Psychosis</topic><topic>Receptors</topic><topic>Research Article</topic><topic>Serotonin</topic><topic>Serotonin S2 receptors</topic><topic>Water content</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, Zhicheng</creatorcontrib><creatorcontrib>Ling, Jianer</creatorcontrib><creatorcontrib>Yu, Jing</creatorcontrib><creatorcontrib>He, Mengzi</creatorcontrib><creatorcontrib>Ni, Pingping</creatorcontrib><creatorcontrib>Zhang, Fang</creatorcontrib><creatorcontrib>Wang, Yizhen</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Social Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Zhicheng</au><au>Ling, Jianer</au><au>Yu, Jing</au><au>He, Mengzi</au><au>Ni, Pingping</au><au>Zhang, Fang</au><au>Wang, Yizhen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotonin 2A receptor function and depression-like behavior in rats model of hypothyroidism</atitle><jtitle>Experimental brain research</jtitle><stitle>Exp Brain Res</stitle><date>2021-08-01</date><risdate>2021</risdate><volume>239</volume><issue>8</issue><spage>2435</spage><epage>2444</epage><pages>2435-2444</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><abstract>Hypothyroidism causes somatic, psychosocial and affective psychosis, including depression-like behaviors. In this study, (hypothyroidism group; HP group) adult male Sprague Dawley (SD) rats were induced to hypothyroidism after 5 weeks of exposure to 0.05% propylthiouracil (PTU) in potable water, control animals (CON group) were given the same amount of water. The following behavioral experiments were conducted, respectively: open-field test (OFT), forced swimming test (FST), tail suspension test (TST). TT
3
and TT
4
levels were measured after the behavior tests and the expression levels of 5-HT
2
A
receptor and 5-HT
2
A
receptor proteins were analyzed in the hippocampus and prefrontal cortex. The level of TT
3
and TT
4
in the HP group rats was much lower than that in the CON group. The hypothyroid rats also showed weight loss, much longer immobility time in tail suspension test and forced swimming test. Besides, 5 weeks of PTU administration was associated with significantly decreased expression levels of 5-HT
2
A
receptor and 5-HT
2
A
receptor proteins compared with control group, which were significantly negatively correlated with immobility time in FST and TST. In conclusion, our results suggest that hypothyroidism induces depressive behaviors through the influence of the serotonin system, and the decreased expression of the 5-HT
2
A
receptor is an important cause of the depressive behaviors in hypothyroidism.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00221-021-06129-1</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3208-0821</orcidid></addata></record> |
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| source | Social Science Premium Collection; Springer Nature |
| subjects | Behavior Biomedical and Life Sciences Biomedicine Complications and side effects Depression, Mental Development and progression Drinking water Emotional behavior Hypothyroidism Mental depression Neurology Neurosciences Open-field behavior Prefrontal cortex Propylthiouracil Psychological aspects Psychosis Receptors Research Article Serotonin Serotonin S2 receptors Water content |
| title | Serotonin 2A receptor function and depression-like behavior in rats model of hypothyroidism |
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