Rare Self-Luminous Mixed-Valence Eu-MOF with a Self-Enhanced Characteristic as a Near-Infrared Fluorescent ECL Probe for Nondestructive Immunodetection

Steady and efficient sensitized emission of Eu2+ to Eu3+ can be achieved through a rare mixed-valence Eu-MOF (L4EuIII 2EuII). Compared with the sensitization of other substances, the similar ion radius and configuration of the extranuclear electron between Eu2+ and Eu3+ make sensitization easier and...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2021-06, Vol.93 (24), p.8613-8621
Main Authors: Zhao, Lu, Song, Xianzhen, Ren, Xiang, Fan, Dawei, Wei, Qin, Wu, Dan
Format: Article
Language:English
Subjects:
Analytical chemistry
Biosensors
Carbon dioxide
Cerium oxides
Chemistry
Cobalt
Cobalt oxides
Damage detection
Electrochemiluminescence
Europium
Fluorescence
Fluorescent indicators
I.R. radiation
Microspheres
Near infrared radiation
Nondestructive testing
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Summary:Steady and efficient sensitized emission of Eu2+ to Eu3+ can be achieved through a rare mixed-valence Eu-MOF (L4EuIII 2EuII). Compared with the sensitization of other substances, the similar ion radius and configuration of the extranuclear electron between Eu2+ and Eu3+ make sensitization easier and more efficient. The sensitization of Eu2+ to Eu3+ is of great assistance for the self-enhanced luminescence of L4EuIII 2EuII, the longer luminous time, and the more stable electrochemiluminescence (ECL) signal. Simultaneously, L4EuIII 2EuII possesses near-infrared (NIR) fluorescence of around 900 nm and a mighty self-luminous characteristic, which render it useful as a NIR fluorescent probe and as a luminophore to establish a NIR ECL biosensor. This NIR biosensor can greatly reduce the damage to the detected samples and even achieve a nondestructive test and improve the detection sensitivity by virtue of strong susceptibility and environmental suitability of NIR. In addition, the CeO2@Co3O4 triple-shelled microspheres further enhanced the ECL intensity due to two redox pairs of Ce3+/Ce4+ and Co2+/Co3+. The NIR ECL biosensor based on these strategies owns an ultrasensitive detection ability of CYFRA 21-1 with a low limit of detection of 1.70 fg/mL and also provides a novel idea for the construction of a highly effective nondestructive immunodetection biosensor.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.1c01531