Evaluation of the potential of total proanthocyanidin content in feces as an intake biomarker

[Display omitted] •Porter method was modified to measure total proanthocyanidins (PAs) in feces.•Total fecal PAs were evaluated as biomarker of PA intake.•Total fecal PAs were associated with PA intake in supplementation preclinical study.•Total fecal PAs were not associated with PA intake in an obs...

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Published in:Food research international 2021-07, Vol.145, p.110390-110390, Article 110390
Main Authors: Magdaleno-Tapia, Cristina, Quifer-Rada, Paola, Rodríguez-Rodríguez, Elena, Estévez-Santiago, Rocío, Waterhouse, Andrew L., Lamuela-Reventós, Rosa M., Olmedilla-Alonso, Begoña, Pérez-Jiménez, Jara
Format: Article
Language:English
Subjects:
Metabolism
Observational study
Polyphenols
Preclinical study
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Summary:[Display omitted] •Porter method was modified to measure total proanthocyanidins (PAs) in feces.•Total fecal PAs were evaluated as biomarker of PA intake.•Total fecal PAs were associated with PA intake in supplementation preclinical study.•Total fecal PAs were not associated with PA intake in an observational study. Due to the health benefits associated with proanthocyanidins (PAs), it is useful to identify dietary PA biomarkers that can be determined by simple methods. Since increased levels of circulating PA metabolites are associated with increased fecal PA content, this study explores the spectrophotometric measurement of fecal PA content and its use as a biomarker of PA intake. To this end, fecal PA content was measured using an adaptation of Porter’s spectrophotometric method in samples from a preclinical study and an observational study. In the former, excretion of 250–400 mg PA polymer equivalents/100 g feces was observed during supplementation and the day after, together with a significant association (p 
ISSN:0963-9969
1873-7145
DOI:10.1016/j.foodres.2021.110390