The impact of deoxynivalenol contaminated diet on performance, immune response, intestine morphology and jejunal gene expression in broiler chicken

The aim of this study was to determine the effects of deoxynivalenol (DON) contaminated diet on performance, immune system, gut morphology and jejunal gene expression in broiler chickens. Eighty-one-day old chicks were randomly allotted into two treatments with 4 replicates (10 birds in each replica...

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Bibliographic Details
Published in:Toxicon (Oxford) 2021-08, Vol.199, p.72-78
Main Authors: Azizi, Tayebe, Daneshyar, Mohsen, Allymehr, Manoochehr, Jalali, Ali Shalizar, Behroozyar, Hamed Khalilvandi, Tukmechi, Amir
Format: Article
Language:English
Subjects:
Claudin-5
Deoxynivalenol
Enzyme activity
Gut morphology
Mucin-2
White blood cell
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Summary:The aim of this study was to determine the effects of deoxynivalenol (DON) contaminated diet on performance, immune system, gut morphology and jejunal gene expression in broiler chickens. Eighty-one-day old chicks were randomly allotted into two treatments with 4 replicates (10 birds in each replication). Experimental diets were the control diet (maize-soybean meal) and an experimentally contaminated diet with 10 mg/kg DON. The results indicated that DON-challenged birds had decreased (P  0.05) by inclusion of DON contaminated diet during the whole experimental period. Dietary addition of DON to the basal diet caused Fabricius bursa relative weight reduction, while increased the abdominal fat and serum triglyceride (TG) concentration (P 
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2021.06.001