Property Regulation of Conjugated Oligoelectrolytes with Polyisocyanide to Achieve Efficient Photodynamic Antibacterial Biomimetic Hydrogels

Fabricating antibacterial hydrogels with antimicrobial drugs and synthetic biocompatible biomimetic hydrogels is a promising strategy for practical medical applications. Here, we report a bicomponent hydrogel composed of a biomimetic polyisocyanopetide (PIC) hydrogel and a photodynamic antibacterial...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2021-06, Vol.13 (24), p.27955-27962
Main Authors: Du, Changsheng, Gao, Dong, Gao, Mengshi, Yuan, Hongbo, Liu, Xiaoning, Wang, Bing, Xing, Chengfen
Format: Article
Language:English
Subjects:
Biological and Medical Applications of Materials and Interfaces
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Summary:Fabricating antibacterial hydrogels with antimicrobial drugs and synthetic biocompatible biomimetic hydrogels is a promising strategy for practical medical applications. Here, we report a bicomponent hydrogel composed of a biomimetic polyisocyanopetide (PIC) hydrogel and a photodynamic antibacterial membrane-intercalating conjugated oligoelectrolyte (COE). The aggregation behavior and aggregate size of the COEs in water can be regulated using the PIC hydrogel, which could induce COEs with higher reactive oxygen species (ROS) production efficiency and increased association of COEs toward bacteria, therefore enhancing the antibacterial efficiency. This strategy provides a facile method for developing biomimetic hydrogels with high antibacterial capability.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.1c06659