Optimal fitting of computer model simulations to first transit cardiac radionuclide curves. II

For pt.I see ibid., vol.36, no.9, p.935-45 (1989). A discrete-time, lumped-parameter mathematical model of the human cardiopulmonary circulation as it appears during a first-transit radionuclide study was described in pt.I. An optimal fitting process is used to match curves obtained from the model t...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 1989-09, Vol.36 (9), p.946-953
Main Authors: Low, L.R., Farison, J.B., Windham, J.P., Potvin, W.J.
Format: Article
Language:English
Subjects:
Algorithms
Biological and medical sciences
Cardiology
Computational modeling
Computer Simulation
Curve fitting
Delay estimation
Heart
Heart - diagnostic imaging
Heart - physiology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Mathematical model
Medical sciences
Miscellaneous. Technology
Models, Cardiovascular
Parameter estimation
Radionuclide Imaging
Radionuclide investigations
Research Design
Testing
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Summary:For pt.I see ibid., vol.36, no.9, p.935-45 (1989). A discrete-time, lumped-parameter mathematical model of the human cardiopulmonary circulation as it appears during a first-transit radionuclide study was described in pt.I. An optimal fitting process is used to match curves obtained from the model to curves obtained from first transit studies in order to estimate the parameters of the subject's heart. The development of the optimization technique is described. The results of testing the effects of overlapping compartments and errors in delay estimates are presented. A parameter determination analysis is performed by applying the optimization algorithm to simulated data. This analysis technique provides a method of estimating many parameters of heart function using a single, simple, rapid procedure.< >
ISSN:0018-9294
1558-2531
DOI:10.1109/10.35303