Modifications on porous absorbable Fe‐based scaffolds for bone applications: A review from corrosion and biocompatibility viewpoints

Iron (Fe) and Fe‐based scaffolds have become a research frontier in absorbable materials which is inherent to their promising mechanical properties including fatigue strength and ductility. Nevertheless, their slow corrosion rate and low biocompatibility have been their major obstacles to be applied...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2022-01, Vol.110 (1), p.18-44
Main Authors: Md Yusop, Abdul Hakim, Al Sakkaf, Ahmed, Nur, Hadi
Format: Article
Language:English
Subjects:
alloying
Alloys - chemistry
Biocompatibility
Biocompatible Materials - chemistry
Biomedical materials
Bone and Bones
coating
Controllability
Corrosion
Corrosion fatigue
Corrosion prevention
Corrosion rate
Ductility
Fatigue strength
Iron
Materials research
Materials science
Mechanical properties
Pore size
Porosity
porous iron
Scaffolds
Structural design
Structural engineering
Surface area
Tensile Strength
topologically ordered design
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Summary:Iron (Fe) and Fe‐based scaffolds have become a research frontier in absorbable materials which is inherent to their promising mechanical properties including fatigue strength and ductility. Nevertheless, their slow corrosion rate and low biocompatibility have been their major obstacles to be applied in clinical applications. Over the last decade, various modifications on porous Fe‐based scaffolds have been performed to ameliorate both properties encompassing surface coating, microstructural alteration via alloying, and advanced topologically order structural design produced by additive manufacturing (AM) techniques. The recent advent of AM produces topologically ordered porous Fe‐based structures with an optimized architecture having controllable pore size and strut thickness, intricate internal design, and larger exposed surface area. This undoubtedly opens up new options for controlling Fe corrosion and its structural strengths. However, the in vitro biocompatibility of the AM porous Fe still needs to be addressed considering its higher corrosion rate due to the larger exposed surface area. This review summarizes the latest progress of the modifications on porous Fe‐based scaffolds with a specific focus on their responses on the corrosion behavior and biocompatibility.
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.34893