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Hippocampal Volumes in Amnestic and Non-Amnestic Mild Cognitive Impairment Types Using Two Common Methods of MCI Classification

Mild cognitive impairment (MCI) types may have distinct neuropathological substrates with hippocampal atrophy particularly common in amnestic MCI (aMCI). However, depending on the MCI classification criteria applied to the sample (e.g., number of abnormal test scores considered or thresholds for imp...

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Bibliographic Details
Published in:Journal of the International Neuropsychological Society 2022-04, Vol.28 (4), p.391-400
Main Authors: Emmert, Natalie A., Reiter, Katherine E., Butts, Alissa, Janecek, Julie K, Agarwal, Mohit, Franczak, Malgorzata, Reuss, James, Klein, Andrew, Wang, Yang, Umfleet, Laura Glass
Format: Article
Language:English
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Summary:Mild cognitive impairment (MCI) types may have distinct neuropathological substrates with hippocampal atrophy particularly common in amnestic MCI (aMCI). However, depending on the MCI classification criteria applied to the sample (e.g., number of abnormal test scores considered or thresholds for impairment), volumetric findings between MCI types may change. Additionally, despite increased clinical use, no prior research has examined volumetric differences in MCI types using the automated volumetric software, Neuroreader™. The present study separately applied the Petersen/Winblad and Jak/Bondi MCI criteria to a clinical sample of older adults (N = 82) who underwent neuropsychological testing and brain MRI. Volumetric data were analyzed using Neuroreader™ and hippocampal volumes were compared between aMCI and non-amnestic MCI (naMCI). T-tests revealed that regardless of MCI classification criteria, hippocampal volume z-scores were significantly lower in aMCI compared to naMCI (p's 
ISSN:1355-6177
1469-7661
DOI:10.1017/S1355617721000564