Au nanoparticle plasmon-enhanced electrochemiluminescence aptasensor based on the 1D/2D PTCA/CoP for diclofenac assay

The combination of localized surface plasmon resonance (LSPR) and electrochemiluminescence (ECL) can be an effective way to amplify the signal intensity. In this work, an ECL aptasensor with 3,4,9,10-perylenetetracarboxylic acid–decorated cobalt phosphate (denoted as PTCA/CoP) as the ECL emitter and...

Full description

Saved in:
Bibliographic Details
Published in:Mikrochimica acta (1966) 2021-07, Vol.188 (7), p.231-231, Article 231
Main Authors: Li, Jingxian, Shan, Xueling, Jiang, Ding, Wang, Wenchang, Xu, Fangmin, Chen, Zhidong
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biosensing Techniques - methods
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Cobalt
Diclofenac
Diclofenac - pharmacology
Diclofenac - therapeutic use
Electrochemical Techniques - methods
Electrochemiluminescence
Electrons
Emitters
Gold
Gold - chemistry
Humans
Metal Nanoparticles - chemistry
Microengineering
Nanochemistry
Nanoparticles
Nanotechnology
Nonsteroidal anti-inflammatory drugs
Original Paper
Phosphates
Silver chloride
Surface plasmon resonance
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The combination of localized surface plasmon resonance (LSPR) and electrochemiluminescence (ECL) can be an effective way to amplify the signal intensity. In this work, an ECL aptasensor with 3,4,9,10-perylenetetracarboxylic acid–decorated cobalt phosphate (denoted as PTCA/CoP) as the ECL emitter and Au nanoparticles (NPs) as plasma was proposed for diclofenac assay. The prepared PTCA/CoP with special 1D/2D structure exhibited good ability and excellent ECL performance. The diclofenac aptamer acted as a bridge to link the PTCA/CoP and Au NPs; thus, the ECL performance of PTCA/CoP was greatly improved due to the plasma effect of Au NPs. Besides, it was found that the ECL signal of the aptasensor was obviously quenched by the introduction of diclofenac, which might be due to the transformation from the LSPR process to the resonance energy transform (RET) process. Under optimal conditions, the difference of ECL intensity was negatively correlated with the concentration of diclofenac in the range 0.1 pM to 10 μM with a low detection limit of 0.072 pM at the potential of −1.8 V vs. Ag/AgCl ( S / N  = 3). The aptasensor was proved to be suitable for the detection of diclofenac in real samples, suggesting its great practicability. Graphical abstract
ISSN:0026-3672
1436-5073
DOI:10.1007/s00604-021-04879-x