The prognostic impact of BIA-derived fat-free mass index in patients with cancer

Reduced muscle mass represents one of the top ranked phenotypic criteria for malnutrition proposed by the Global Leadership Initiative on Malnutrition. Although height-indexed fat-free mass (FFMI) thresholds have been proposed as useful surrogate measures of reduced muscle mass, the independent prog...

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Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2021-06, Vol.40 (6), p.3901-3907
Main Authors: Cereda, Emanuele, Pedrazzoli, Paolo, Lobascio, Federica, Masi, Sara, Crotti, Silvia, Klersy, Catherine, Turri, Annalisa, Stobäus, Nicole, Tank, Maja, Franz, Kristina, Cutti, Sara, Giaquinto, Ester, Filippi, Andrea Riccardo, Norman, Kristina, Caccialanza, Riccardo
Format: Article
Language:English
Subjects:
Bioelectric impedance analysis (BIA)
Cancer
Fat-free mass index (FFMI)
Mortality
Prognosis
Quality of life (QoL)
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Summary:Reduced muscle mass represents one of the top ranked phenotypic criteria for malnutrition proposed by the Global Leadership Initiative on Malnutrition. Although height-indexed fat-free mass (FFMI) thresholds have been proposed as useful surrogate measures of reduced muscle mass, the independent prognostic value of BIA-derived FFMI by bioelectric impedance analysis (BIA) in patients with cancer still needs to be fully explored. Data on body mass index (BMI), 6-month percentage of weight loss (%WL), FFMI by BIA and quality of life (QoL by EORTC Quality of Life Questionnaire [EORTC QLQ-C30]) of Italian and German patients observed prospectively until death or censoring were used (N = 1217). Patients were stratified in 5 risk categories according to a robustly validated scoring system based on BMI and %WL. Low FFMI was defined as follows: men,
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2021.04.024