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Oral health condition in cancer patients under bisphosphonate therapy

Objectives To investigate the association of oral health condition with the occurrence of medication-related osteonecrosis of the jaw (MRONJ) in a cancer population. Methods A multicenter cross-sectional study was conducted with cancer patients exposed to bisphosphonates for at least 7 months. Denta...

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Published in:Supportive care in cancer 2021-12, Vol.29 (12), p.7687-7694
Main Authors: Jardim Caldas, Rogério, Spíndola Antunes, Héliton, de Oliveira Rodini Pegoraro, Camila, Ribeiro Guedes, Fábio, da Silva Santos, Paulo Sérgio
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container_title Supportive care in cancer
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creator Jardim Caldas, Rogério
Spíndola Antunes, Héliton
de Oliveira Rodini Pegoraro, Camila
Ribeiro Guedes, Fábio
da Silva Santos, Paulo Sérgio
description Objectives To investigate the association of oral health condition with the occurrence of medication-related osteonecrosis of the jaw (MRONJ) in a cancer population. Methods A multicenter cross-sectional study was conducted with cancer patients exposed to bisphosphonates for at least 7 months. Dental and periodontal conditions were assessed by epidemiological indices. Results The sample consisted of 80 patients under bisphosphonate therapy, nine of which were allocated to group 1 (with MRONJ) and 71 to group 2 (without MRONJ). Osteonecrosis cases presented 19 decayed, missing, and filled teeth on average. Moderate gingival inflammation was noted in both groups and together with severe inflammation exceeded 50% of the groups. The presence of dental calculus was detected in about half of the individuals in both groups. Shallow periodontal pockets were detected in about 25% of both groups. Deep periodontal pockets were more prevalent among patients with osteonecrosis. Regular oral hygiene was detected in approximately 25% of individuals in both groups. There was a strong positive correlation between the clinical staging of osteonecrosis and decayed, missing, and filled teeth index (DMFTI). Conclusions Patients had a poor oral health condition. All but one osteonecrosis case had no previous history of tooth extraction; oral infections seemed to play a major role in the development of bone necrosis. Advanced osteonecrosis stages were associated with a higher DMFTI.
doi_str_mv 10.1007/s00520-021-06362-y
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Methods A multicenter cross-sectional study was conducted with cancer patients exposed to bisphosphonates for at least 7 months. Dental and periodontal conditions were assessed by epidemiological indices. Results The sample consisted of 80 patients under bisphosphonate therapy, nine of which were allocated to group 1 (with MRONJ) and 71 to group 2 (without MRONJ). Osteonecrosis cases presented 19 decayed, missing, and filled teeth on average. Moderate gingival inflammation was noted in both groups and together with severe inflammation exceeded 50% of the groups. The presence of dental calculus was detected in about half of the individuals in both groups. Shallow periodontal pockets were detected in about 25% of both groups. Deep periodontal pockets were more prevalent among patients with osteonecrosis. Regular oral hygiene was detected in approximately 25% of individuals in both groups. There was a strong positive correlation between the clinical staging of osteonecrosis and decayed, missing, and filled teeth index (DMFTI). Conclusions Patients had a poor oral health condition. All but one osteonecrosis case had no previous history of tooth extraction; oral infections seemed to play a major role in the development of bone necrosis. Advanced osteonecrosis stages were associated with a higher DMFTI.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-021-06362-y</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Bisphosphonates ; Bone diseases ; Cancer ; Cancer patients ; Care and treatment ; Dental caries ; Disodium pamidronate ; Epidemiology ; Gangrene ; Gum disease ; Health aspects ; Hygiene ; Jaw ; Medical research ; Medicine ; Medicine &amp; Public Health ; Medicine, Experimental ; Nursing ; Nursing Research ; Oncology ; Oral health ; Oral hygiene ; Original Article ; Pain Medicine ; Rehabilitation Medicine ; Side effects ; Tooth extractions</subject><ispartof>Supportive care in cancer, 2021-12, Vol.29 (12), p.7687-7694</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-e022940ce35c5ea975786e6def7bb492d92cda68b164d58010a5ca908581de483</citedby><cites>FETCH-LOGICAL-c419t-e022940ce35c5ea975786e6def7bb492d92cda68b164d58010a5ca908581de483</cites><orcidid>0000-0002-1076-8019 ; 0000-0002-0674-3759 ; 0000-0001-6410-0551 ; 0000-0002-8763-4967</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2586194902/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2586194902?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21394,21395,27924,27925,33611,33612,34530,34531,43733,44115,74221,74639</link.rule.ids></links><search><creatorcontrib>Jardim Caldas, Rogério</creatorcontrib><creatorcontrib>Spíndola Antunes, Héliton</creatorcontrib><creatorcontrib>de Oliveira Rodini Pegoraro, Camila</creatorcontrib><creatorcontrib>Ribeiro Guedes, Fábio</creatorcontrib><creatorcontrib>da Silva Santos, Paulo Sérgio</creatorcontrib><title>Oral health condition in cancer patients under bisphosphonate therapy</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><description>Objectives To investigate the association of oral health condition with the occurrence of medication-related osteonecrosis of the jaw (MRONJ) in a cancer population. Methods A multicenter cross-sectional study was conducted with cancer patients exposed to bisphosphonates for at least 7 months. Dental and periodontal conditions were assessed by epidemiological indices. Results The sample consisted of 80 patients under bisphosphonate therapy, nine of which were allocated to group 1 (with MRONJ) and 71 to group 2 (without MRONJ). Osteonecrosis cases presented 19 decayed, missing, and filled teeth on average. Moderate gingival inflammation was noted in both groups and together with severe inflammation exceeded 50% of the groups. The presence of dental calculus was detected in about half of the individuals in both groups. Shallow periodontal pockets were detected in about 25% of both groups. Deep periodontal pockets were more prevalent among patients with osteonecrosis. Regular oral hygiene was detected in approximately 25% of individuals in both groups. There was a strong positive correlation between the clinical staging of osteonecrosis and decayed, missing, and filled teeth index (DMFTI). Conclusions Patients had a poor oral health condition. All but one osteonecrosis case had no previous history of tooth extraction; oral infections seemed to play a major role in the development of bone necrosis. 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Methods A multicenter cross-sectional study was conducted with cancer patients exposed to bisphosphonates for at least 7 months. Dental and periodontal conditions were assessed by epidemiological indices. Results The sample consisted of 80 patients under bisphosphonate therapy, nine of which were allocated to group 1 (with MRONJ) and 71 to group 2 (without MRONJ). Osteonecrosis cases presented 19 decayed, missing, and filled teeth on average. Moderate gingival inflammation was noted in both groups and together with severe inflammation exceeded 50% of the groups. The presence of dental calculus was detected in about half of the individuals in both groups. Shallow periodontal pockets were detected in about 25% of both groups. Deep periodontal pockets were more prevalent among patients with osteonecrosis. Regular oral hygiene was detected in approximately 25% of individuals in both groups. There was a strong positive correlation between the clinical staging of osteonecrosis and decayed, missing, and filled teeth index (DMFTI). Conclusions Patients had a poor oral health condition. All but one osteonecrosis case had no previous history of tooth extraction; oral infections seemed to play a major role in the development of bone necrosis. Advanced osteonecrosis stages were associated with a higher DMFTI.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00520-021-06362-y</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1076-8019</orcidid><orcidid>https://orcid.org/0000-0002-0674-3759</orcidid><orcidid>https://orcid.org/0000-0001-6410-0551</orcidid><orcidid>https://orcid.org/0000-0002-8763-4967</orcidid></addata></record>
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subjects Bisphosphonates
Bone diseases
Cancer
Cancer patients
Care and treatment
Dental caries
Disodium pamidronate
Epidemiology
Gangrene
Gum disease
Health aspects
Hygiene
Jaw
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Nursing
Nursing Research
Oncology
Oral health
Oral hygiene
Original Article
Pain Medicine
Rehabilitation Medicine
Side effects
Tooth extractions
title Oral health condition in cancer patients under bisphosphonate therapy
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