Tetanus vaccination in pregnant women: a systematic review and meta-analysis of the global literature

This study aimed to determine the effect of several factors on the uptake of tetanus vaccination in pregnant women. This is a systematic review and meta-analysis of the global literature. The search strategy was carried out in the EMBASE and MEDLINE (Pubmed) databases, without language restrictions....

Full description

Saved in:
Bibliographic Details
Published in:Public health (London) 2021-07, Vol.196, p.43-51
Main Authors: Faria, A.P.V., da Silva, T.P.R., Duarte, C.K., Mendes, L.L., Santos, F.B.O., Matozinhos, F.P.
Format: Article
Language:English
Subjects:
Confidence intervals
Heterogeneity
Immunization
Influenza
Meta-analysis
Pregnancy
Prenatal care
Public health
Review systematic
Search methods
Subgroups
Systematic review
Tetanus
Tetanus toxoid
Uptake
Vaccination
Vaccines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed to determine the effect of several factors on the uptake of tetanus vaccination in pregnant women. This is a systematic review and meta-analysis of the global literature. The search strategy was carried out in the EMBASE and MEDLINE (Pubmed) databases, without language restrictions. The databases were searched from the beginning until May 2020. Fixed and random effect models were applied according to the methodological heterogeneity between the included studies. The I2 test was performed to assess the magnitude of the heterogeneity. The results were presented as a grouped odds ratio (OR) with a 95% confidence interval (CI) and a significance level of 0.05. The initial search strategy generated 14,349 original articles. In total, 31 studies met all inclusion criteria and 20 articles were included in the meta-analysis. The grouped and subgroup analyses showed a significant association between tetanus vaccination and the following factors: higher number of prenatal visits (OR: 2.00; 95% CI: 1.17–3.42), higher maternal age (OR: 1.24, 95% CI: 1.02–1.50), being single (OR: 1.41; 95% CI: 1.20–1.65), professional vaccine guidance (OR: 9.00; 95% CI: 1.81–44.75) and uptake of influenza vaccine (OR: 5.87; 95% CI: 1.39–24.73). The uptake of tetanus vaccine in pregnant women is associated with various factors. The identification of these factors is an important step towards the implementation of public health strategies aimed at improving immunisation against tetanus in pregnant women.
ISSN:0033-3506
1476-5616
DOI:10.1016/j.puhe.2021.04.019