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Effects of 25‐hydroxyvitamin D3 on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus
BACKGROUND With the development of intensive farming, long‐term exposure of pigs to poor light conditions is not conducive to the production of vitamin D3, and vitamin D3 deficiency could affect absorption and metabolism of calcium (Ca) and phosphorus (P). 25‐Hydroxyvitamin D3 (25OHD3) has higher bi...
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| Published in: | Journal of the science of food and agriculture 2022-01, Vol.102 (2), p.597-606 |
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| container_end_page | 606 |
| container_issue | 2 |
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| container_title | Journal of the science of food and agriculture |
| container_volume | 102 |
| creator | Zhang, Lianhua Yang, Ming Piao, Xiangshu |
| description | BACKGROUND
With the development of intensive farming, long‐term exposure of pigs to poor light conditions is not conducive to the production of vitamin D3, and vitamin D3 deficiency could affect absorption and metabolism of calcium (Ca) and phosphorus (P). 25‐Hydroxyvitamin D3 (25OHD3) has higher bioactivity than regular vitamin D3. This study investigated the effects of 25OHD3 on performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed with low Ca‐P diet.
RESULTS
It was found that a low Ca‐P diet supplemented with 50 μg/kg 25OHD3 (NC + 25‐D) improved (P |
| doi_str_mv | 10.1002/jsfa.11388 |
| format | article |
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With the development of intensive farming, long‐term exposure of pigs to poor light conditions is not conducive to the production of vitamin D3, and vitamin D3 deficiency could affect absorption and metabolism of calcium (Ca) and phosphorus (P). 25‐Hydroxyvitamin D3 (25OHD3) has higher bioactivity than regular vitamin D3. This study investigated the effects of 25OHD3 on performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed with low Ca‐P diet.
RESULTS
It was found that a low Ca‐P diet supplemented with 50 μg/kg 25OHD3 (NC + 25‐D) improved (P < 0.05) average daily gain (ADG) in phase 2 and in the overall period of the experiment, and increased (P < 0.05) the immunoglobulin G (IgG), immunoglobulin A (IgA), catalase (CAT), bone‐specific alkaline phosphatase (BALP), and osteocalcin (OC) serum content on day 28 compared with a low Ca‐P diet (NC), but no differences were observed between a normal Ca‐P diet (PC) and the NC + 25‐D diet. Compared with NC, the abundance of Firmicutes was higher (P < 0.05) in PC and NC + 25‐D. NC + 25‐D decreased (P < 0.05) the abundance of Streptococcaceae compared with PC and NC, and increased (P < 0.05) the abundance of Lachnospiraceae compared with NC. Serum 25OHD3 was negatively correlated with the abundance of fecal Streptococcaceae (P < 0.05), and positively correlated with the abundance of fecal Lachnospiraceae (P < 0.05).
CONCLUSION
Supplementation of 25OHD3 in a low Ca‐P diet improved serum immunity, bone biochemical parameters, and fecal microbiota such as decreased Streptococcaceae abundance and increased Lachnospiraceae abundance, which could subsequently promote growth of piglets. The effects were similar to that of a normal Ca‐P diet. © 2021 Society of Chemical Industry.]]></description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.11388</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>25-Hydroxyvitamin D ; 25‐hydroxyvitamin D3 ; Abundance ; Alkaline phosphatase ; Biological activity ; Biomedical materials ; Calcium ; Calcium absorption ; Calcium metabolism ; Catalase ; Diet ; fecal microbiota ; Fecal microflora ; Feces ; IgG antibody ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulins ; Intensive farming ; Lachnospiraceae ; Metabolites ; Microbiota ; Nutrient deficiency ; Osteocalcin ; Parameters ; Phosphorus ; piglets ; serum parameters ; Swine ; Vitamin D3</subject><ispartof>Journal of the science of food and agriculture, 2022-01, Vol.102 (2), p.597-606</ispartof><rights>2021 Society of Chemical Industry.</rights><rights>Copyright © 2022 Society of Chemical Industry</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-5913-8889 ; 0000-0003-4604-452X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Zhang, Lianhua</creatorcontrib><creatorcontrib>Yang, Ming</creatorcontrib><creatorcontrib>Piao, Xiangshu</creatorcontrib><title>Effects of 25‐hydroxyvitamin D3 on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus</title><title>Journal of the science of food and agriculture</title><description><![CDATA[BACKGROUND
With the development of intensive farming, long‐term exposure of pigs to poor light conditions is not conducive to the production of vitamin D3, and vitamin D3 deficiency could affect absorption and metabolism of calcium (Ca) and phosphorus (P). 25‐Hydroxyvitamin D3 (25OHD3) has higher bioactivity than regular vitamin D3. This study investigated the effects of 25OHD3 on performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed with low Ca‐P diet.
RESULTS
It was found that a low Ca‐P diet supplemented with 50 μg/kg 25OHD3 (NC + 25‐D) improved (P < 0.05) average daily gain (ADG) in phase 2 and in the overall period of the experiment, and increased (P < 0.05) the immunoglobulin G (IgG), immunoglobulin A (IgA), catalase (CAT), bone‐specific alkaline phosphatase (BALP), and osteocalcin (OC) serum content on day 28 compared with a low Ca‐P diet (NC), but no differences were observed between a normal Ca‐P diet (PC) and the NC + 25‐D diet. Compared with NC, the abundance of Firmicutes was higher (P < 0.05) in PC and NC + 25‐D. NC + 25‐D decreased (P < 0.05) the abundance of Streptococcaceae compared with PC and NC, and increased (P < 0.05) the abundance of Lachnospiraceae compared with NC. Serum 25OHD3 was negatively correlated with the abundance of fecal Streptococcaceae (P < 0.05), and positively correlated with the abundance of fecal Lachnospiraceae (P < 0.05).
CONCLUSION
Supplementation of 25OHD3 in a low Ca‐P diet improved serum immunity, bone biochemical parameters, and fecal microbiota such as decreased Streptococcaceae abundance and increased Lachnospiraceae abundance, which could subsequently promote growth of piglets. The effects were similar to that of a normal Ca‐P diet. © 2021 Society of Chemical Industry.]]></description><subject>25-Hydroxyvitamin D</subject><subject>25‐hydroxyvitamin D3</subject><subject>Abundance</subject><subject>Alkaline phosphatase</subject><subject>Biological activity</subject><subject>Biomedical materials</subject><subject>Calcium</subject><subject>Calcium absorption</subject><subject>Calcium metabolism</subject><subject>Catalase</subject><subject>Diet</subject><subject>fecal microbiota</subject><subject>Fecal microflora</subject><subject>Feces</subject><subject>IgG antibody</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulins</subject><subject>Intensive farming</subject><subject>Lachnospiraceae</subject><subject>Metabolites</subject><subject>Microbiota</subject><subject>Nutrient deficiency</subject><subject>Osteocalcin</subject><subject>Parameters</subject><subject>Phosphorus</subject><subject>piglets</subject><subject>serum parameters</subject><subject>Swine</subject><subject>Vitamin D3</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkc1u1TAQha0KpF5KN30CS2xY3JSxHednWZWWgiqxoF1bjjPu9VUSBzsh3B2P0MfgufokOG1XLKw50hx_c6RDyBmDcwbAP-2j1eeMiao6IhsGdZkBMHhDNmnJM8lyfkzexbgHgLouig35e2UtmilSbymXT38ed4c2-N-HX27SvRvoZ0H9QB-CX6YdHTFYH3o9GNzSiGHu6aiD7nHCELc0gXRHe2eCb5yf9JbqoaVpqxvfuQkjTcAF9YAtHd1Dh-msTbp1q1pcutD5hSaIcQm9fh53PqYX5vievLW6i3j6Ok_I_fXV3eVNdvv9y9fLi9tsZKWospxDzg0voayrkjWAdc14I0zBuDDW2EqavGIcMC100bbSmEai0BIbbFusxQn5-MIdg_85Y5xU76LBrkux_RwVl7koQcqaJeuH_6x7P4chpVO8gDIlKeQKZC-uxXV4UGNwvQ4HxUCtjam1MfXcmPr24_riWYl_qlSPRw</recordid><startdate>20220130</startdate><enddate>20220130</enddate><creator>Zhang, Lianhua</creator><creator>Yang, Ming</creator><creator>Piao, Xiangshu</creator><general>John Wiley & Sons, Ltd</general><general>John Wiley and Sons, Limited</general><scope>7QF</scope><scope>7QL</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5913-8889</orcidid><orcidid>https://orcid.org/0000-0003-4604-452X</orcidid></search><sort><creationdate>20220130</creationdate><title>Effects of 25‐hydroxyvitamin D3 on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus</title><author>Zhang, Lianhua ; Yang, Ming ; Piao, Xiangshu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1738-42042c27079871b0e9912b3c6123cfcf85c48120ee99a6dd5ccb5e3a5ebedde93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>25-Hydroxyvitamin D</topic><topic>25‐hydroxyvitamin D3</topic><topic>Abundance</topic><topic>Alkaline phosphatase</topic><topic>Biological activity</topic><topic>Biomedical materials</topic><topic>Calcium</topic><topic>Calcium absorption</topic><topic>Calcium metabolism</topic><topic>Catalase</topic><topic>Diet</topic><topic>fecal microbiota</topic><topic>Fecal microflora</topic><topic>Feces</topic><topic>IgG antibody</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulins</topic><topic>Intensive farming</topic><topic>Lachnospiraceae</topic><topic>Metabolites</topic><topic>Microbiota</topic><topic>Nutrient deficiency</topic><topic>Osteocalcin</topic><topic>Parameters</topic><topic>Phosphorus</topic><topic>piglets</topic><topic>serum parameters</topic><topic>Swine</topic><topic>Vitamin D3</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Lianhua</creatorcontrib><creatorcontrib>Yang, Ming</creatorcontrib><creatorcontrib>Piao, Xiangshu</creatorcontrib><collection>Aluminium Industry Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Lianhua</au><au>Yang, Ming</au><au>Piao, Xiangshu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of 25‐hydroxyvitamin D3 on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus</atitle><jtitle>Journal of the science of food and agriculture</jtitle><date>2022-01-30</date><risdate>2022</risdate><volume>102</volume><issue>2</issue><spage>597</spage><epage>606</epage><pages>597-606</pages><issn>0022-5142</issn><eissn>1097-0010</eissn><abstract><![CDATA[BACKGROUND
With the development of intensive farming, long‐term exposure of pigs to poor light conditions is not conducive to the production of vitamin D3, and vitamin D3 deficiency could affect absorption and metabolism of calcium (Ca) and phosphorus (P). 25‐Hydroxyvitamin D3 (25OHD3) has higher bioactivity than regular vitamin D3. This study investigated the effects of 25OHD3 on performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed with low Ca‐P diet.
RESULTS
It was found that a low Ca‐P diet supplemented with 50 μg/kg 25OHD3 (NC + 25‐D) improved (P < 0.05) average daily gain (ADG) in phase 2 and in the overall period of the experiment, and increased (P < 0.05) the immunoglobulin G (IgG), immunoglobulin A (IgA), catalase (CAT), bone‐specific alkaline phosphatase (BALP), and osteocalcin (OC) serum content on day 28 compared with a low Ca‐P diet (NC), but no differences were observed between a normal Ca‐P diet (PC) and the NC + 25‐D diet. Compared with NC, the abundance of Firmicutes was higher (P < 0.05) in PC and NC + 25‐D. NC + 25‐D decreased (P < 0.05) the abundance of Streptococcaceae compared with PC and NC, and increased (P < 0.05) the abundance of Lachnospiraceae compared with NC. Serum 25OHD3 was negatively correlated with the abundance of fecal Streptococcaceae (P < 0.05), and positively correlated with the abundance of fecal Lachnospiraceae (P < 0.05).
CONCLUSION
Supplementation of 25OHD3 in a low Ca‐P diet improved serum immunity, bone biochemical parameters, and fecal microbiota such as decreased Streptococcaceae abundance and increased Lachnospiraceae abundance, which could subsequently promote growth of piglets. The effects were similar to that of a normal Ca‐P diet. © 2021 Society of Chemical Industry.]]></abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/jsfa.11388</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5913-8889</orcidid><orcidid>https://orcid.org/0000-0003-4604-452X</orcidid></addata></record> |
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| ispartof | Journal of the science of food and agriculture, 2022-01, Vol.102 (2), p.597-606 |
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| language | eng |
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| source | Wiley |
| subjects | 25-Hydroxyvitamin D 25‐hydroxyvitamin D3 Abundance Alkaline phosphatase Biological activity Biomedical materials Calcium Calcium absorption Calcium metabolism Catalase Diet fecal microbiota Fecal microflora Feces IgG antibody Immunoglobulin A Immunoglobulin G Immunoglobulins Intensive farming Lachnospiraceae Metabolites Microbiota Nutrient deficiency Osteocalcin Parameters Phosphorus piglets serum parameters Swine Vitamin D3 |
| title | Effects of 25‐hydroxyvitamin D3 on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus |
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