Non-canonical functions of autophagy proteins in immunity and infection

The molecular machinery of macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes, remodels membranes by lipid phosphorylation and conjugation of LC3 and GABARAP proteins. In recent year it has become clear that these membrane modifications also regulate endo- and e...

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Bibliographic Details
Published in:Molecular aspects of medicine 2021-12, Vol.82, p.100987-100987, Article 100987
Main Author: Münz, Christian
Format: Article
Language:English
Subjects:
Antigen Presentation
Autophagy
Exocytosis
Humans
Inflammation
LC3-Associated phagocytosis (LAP)
Lysosomes
MHC restricted Antigen presentation
Viral envelope
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Summary:The molecular machinery of macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes, remodels membranes by lipid phosphorylation and conjugation of LC3 and GABARAP proteins. In recent year it has become clear that these membrane modifications also regulate endo- and exocytosis. Here I will discuss recent evidence of how such non-canonical functions of the macroautophagy machinery with its autophagy related gene (atg) products influences infectious viral particle secretion, inflammation, and MHC restricted antigen presentation. Especially LC3-Associated Phagocytosis and ATG supported exocytosis will be high-lighted during immunity and infection.
ISSN:0098-2997
1872-9452
DOI:10.1016/j.mam.2021.100987