Encapsulation and controlled release of an antimalarial drug using surface functionalized mesoporous silica nanocarriers

Herein, we report the encapsulation and release of antimalarial drug quinine (QN) using three nanocarriers, including MCM-41 ( 1 ), and its 3-aminopropyl silane (aMCM-41 ( 2 )) and 3-phenylpropyl silane (pMCM-41 ( 3 )) surface functionalized derivatives. The pH and thermal optimization effects on QN...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2021-06, Vol.9 (25), p.543-546
Main Authors: Hirayama, Haruka, Amolegbe, Saliu Alao, Islam, Md. Saidul, Rahman, Mohammad Atiqur, Goto, Nonoka, Sekine, Yoshihiro, Hayami, Shinya
Format: Article
Language:English
Subjects:
Controlled release
Encapsulation
Malaria
Optimization
Quinine
Silanes
Silica
Silicon dioxide
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Summary:Herein, we report the encapsulation and release of antimalarial drug quinine (QN) using three nanocarriers, including MCM-41 ( 1 ), and its 3-aminopropyl silane (aMCM-41 ( 2 )) and 3-phenylpropyl silane (pMCM-41 ( 3 )) surface functionalized derivatives. The pH and thermal optimization effects on QN adsorption and release from 1 , 2 and 3 were investigated. The pH and thermal optimization effects on the encapsulation and release of antimalarial drug quinine using three nanocarriers, including MCM-41, and its 3-aminopropyl silane and 3-phenylpropyl silane functionalized derivatives, were investigated.
ISSN:2050-750X
2050-7518
DOI:10.1039/d1tb00954k