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Clinicopathological features of sporadic MSI colorectal cancer and Lynch syndrome: a single-center retrospective cohort study
Background The clinical and pathological features of sporadic microsatellite instability-high (MSI) colorectal cancer (CRC) are still unclear. The present study aimed to clarify the clinicopathological features of sporadic MSI CRC in comparison with those of Lynch syndrome (LS) exploratorily. Method...
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| Published in: | International journal of clinical oncology 2021-10, Vol.26 (10), p.1881-1889 |
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| Main Authors: | , , , , , , , , , |
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| container_end_page | 1889 |
| container_issue | 10 |
| container_start_page | 1881 |
| container_title | International journal of clinical oncology |
| container_volume | 26 |
| creator | Nakayama, Yujiro Iijima, Takeru Inokuchi, Takuhiko Kojika, Ekumi Takao, Misato Takao, Akinari Koizumi, Koichi Horiguchi, Shin-ichiro Hishima, Tsunekazu Yamaguchi, Tatsuro |
| description | Background
The clinical and pathological features of sporadic microsatellite instability-high (MSI) colorectal cancer (CRC) are still unclear. The present study aimed to clarify the clinicopathological features of sporadic MSI CRC in comparison with those of Lynch syndrome (LS) exploratorily.
Methods
The present study was a single-center, retrospective cohort study. Sporadic MSI CRC was defined as MSI CRC with aberrant promoter hypermethylation of the
MLH1
gene, while hereditary MSI CRC was defined colorectal cancer in patients with LS.
Results
In total, 2653 patients were enrolled; of these, 120 (4.5%) had MSI CRC, 98 had sporadic MSI CRC, and 22 had LS. Patients with sporadic MSI CRC were significantly older (
p
|
| doi_str_mv | 10.1007/s10147-021-01968-y |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2543709563</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2573916540</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-b3341dce7d395fd2ef3b54b6ce083a6dd609d7ccc539541ded05648462e8c1d03</originalsourceid><addsrcrecordid>eNp9kU2LFDEQhhtRcN3dP-Ap4MVLNN-Z9iaDHwsjHtY9h0yleqaXnqRN0kIf_O9mHUHYw56qoJ73parernvN2TvOmH1fOOPKUiY4Zbw3G7o-6y64kpZaa8Xz1kvFaW-Eftm9KuWeMW6NFhfd7-00xhHS7OsxTekwgp_IgL4uGQtJAylzyj6MQL7d3hBoSEaojQEfATPxMZDdGuFIyhpDTif8QDwpYzxMSAFjbUzGmlOZm278hc3jmHIlpS5hvepeDH4qeP2vXnZ3nz_92H6lu-9fbrYfdxSUEpXuZds-ANogez0EgYPca7U3gGwjvQnBsD5YANBt3kgMTBu1UUbgBnhg8rJ7e_adc_q5YKnuNBbAafIR01Kc0O1VrNdGNvTNI_Q-LTm27RplZc-NVg-G4kxBu6xkHNycx5PPq-PMPSTizom4loj7m4hbm0ieRaXB8YD5v_UTqj-7apFP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2573916540</pqid></control><display><type>article</type><title>Clinicopathological features of sporadic MSI colorectal cancer and Lynch syndrome: a single-center retrospective cohort study</title><source>Springer Nature</source><creator>Nakayama, Yujiro ; Iijima, Takeru ; Inokuchi, Takuhiko ; Kojika, Ekumi ; Takao, Misato ; Takao, Akinari ; Koizumi, Koichi ; Horiguchi, Shin-ichiro ; Hishima, Tsunekazu ; Yamaguchi, Tatsuro</creator><creatorcontrib>Nakayama, Yujiro ; Iijima, Takeru ; Inokuchi, Takuhiko ; Kojika, Ekumi ; Takao, Misato ; Takao, Akinari ; Koizumi, Koichi ; Horiguchi, Shin-ichiro ; Hishima, Tsunekazu ; Yamaguchi, Tatsuro</creatorcontrib><description>Background
The clinical and pathological features of sporadic microsatellite instability-high (MSI) colorectal cancer (CRC) are still unclear. The present study aimed to clarify the clinicopathological features of sporadic MSI CRC in comparison with those of Lynch syndrome (LS) exploratorily.
Methods
The present study was a single-center, retrospective cohort study. Sporadic MSI CRC was defined as MSI CRC with aberrant promoter hypermethylation of the
MLH1
gene, while hereditary MSI CRC was defined colorectal cancer in patients with LS.
Results
In total, 2653 patients were enrolled; of these, 120 (4.5%) had MSI CRC, 98 had sporadic MSI CRC, and 22 had LS. Patients with sporadic MSI CRC were significantly older (
p
< 0.001) than those with LS and had a right-sided colonic tumor (
p
< 0.001) which was pathologically poorly differentiated or mucinous (
p
= 0.025). The overall survival rate was significantly lower in patients with stage I, II or III MSI CRC than in those with LS (
p
= 0.024). However, the recurrence-free survival rate did not differ significantly (
p
= 0.85).
Conclusions
We concluded that patients with sporadic MSI are significantly older, tumors more likely to locate in the right-sided colon, pathologically poorly differentiated or mucinous, and worse overall survival than in those with LS.</description><identifier>ISSN: 1341-9625</identifier><identifier>EISSN: 1437-7772</identifier><identifier>DOI: 10.1007/s10147-021-01968-y</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Cancer ; Cancer Research ; Cohort analysis ; Colorectal cancer ; Colorectal carcinoma ; Genetic disorders ; Medicine ; Medicine & Public Health ; Microsatellite instability ; MLH1 protein ; Oncology ; Original Article ; Patients ; Surgical Oncology ; Survival ; Tumors</subject><ispartof>International journal of clinical oncology, 2021-10, Vol.26 (10), p.1881-1889</ispartof><rights>Japan Society of Clinical Oncology 2021</rights><rights>Japan Society of Clinical Oncology 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-b3341dce7d395fd2ef3b54b6ce083a6dd609d7ccc539541ded05648462e8c1d03</citedby><cites>FETCH-LOGICAL-c442t-b3341dce7d395fd2ef3b54b6ce083a6dd609d7ccc539541ded05648462e8c1d03</cites><orcidid>0000-0001-8454-1995</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Nakayama, Yujiro</creatorcontrib><creatorcontrib>Iijima, Takeru</creatorcontrib><creatorcontrib>Inokuchi, Takuhiko</creatorcontrib><creatorcontrib>Kojika, Ekumi</creatorcontrib><creatorcontrib>Takao, Misato</creatorcontrib><creatorcontrib>Takao, Akinari</creatorcontrib><creatorcontrib>Koizumi, Koichi</creatorcontrib><creatorcontrib>Horiguchi, Shin-ichiro</creatorcontrib><creatorcontrib>Hishima, Tsunekazu</creatorcontrib><creatorcontrib>Yamaguchi, Tatsuro</creatorcontrib><title>Clinicopathological features of sporadic MSI colorectal cancer and Lynch syndrome: a single-center retrospective cohort study</title><title>International journal of clinical oncology</title><addtitle>Int J Clin Oncol</addtitle><description>Background
The clinical and pathological features of sporadic microsatellite instability-high (MSI) colorectal cancer (CRC) are still unclear. The present study aimed to clarify the clinicopathological features of sporadic MSI CRC in comparison with those of Lynch syndrome (LS) exploratorily.
Methods
The present study was a single-center, retrospective cohort study. Sporadic MSI CRC was defined as MSI CRC with aberrant promoter hypermethylation of the
MLH1
gene, while hereditary MSI CRC was defined colorectal cancer in patients with LS.
Results
In total, 2653 patients were enrolled; of these, 120 (4.5%) had MSI CRC, 98 had sporadic MSI CRC, and 22 had LS. Patients with sporadic MSI CRC were significantly older (
p
< 0.001) than those with LS and had a right-sided colonic tumor (
p
< 0.001) which was pathologically poorly differentiated or mucinous (
p
= 0.025). The overall survival rate was significantly lower in patients with stage I, II or III MSI CRC than in those with LS (
p
= 0.024). However, the recurrence-free survival rate did not differ significantly (
p
= 0.85).
Conclusions
We concluded that patients with sporadic MSI are significantly older, tumors more likely to locate in the right-sided colon, pathologically poorly differentiated or mucinous, and worse overall survival than in those with LS.</description><subject>Cancer</subject><subject>Cancer Research</subject><subject>Cohort analysis</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Genetic disorders</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microsatellite instability</subject><subject>MLH1 protein</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Patients</subject><subject>Surgical Oncology</subject><subject>Survival</subject><subject>Tumors</subject><issn>1341-9625</issn><issn>1437-7772</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kU2LFDEQhhtRcN3dP-Ap4MVLNN-Z9iaDHwsjHtY9h0yleqaXnqRN0kIf_O9mHUHYw56qoJ73parernvN2TvOmH1fOOPKUiY4Zbw3G7o-6y64kpZaa8Xz1kvFaW-Eftm9KuWeMW6NFhfd7-00xhHS7OsxTekwgp_IgL4uGQtJAylzyj6MQL7d3hBoSEaojQEfATPxMZDdGuFIyhpDTif8QDwpYzxMSAFjbUzGmlOZm278hc3jmHIlpS5hvepeDH4qeP2vXnZ3nz_92H6lu-9fbrYfdxSUEpXuZds-ANogez0EgYPca7U3gGwjvQnBsD5YANBt3kgMTBu1UUbgBnhg8rJ7e_adc_q5YKnuNBbAafIR01Kc0O1VrNdGNvTNI_Q-LTm27RplZc-NVg-G4kxBu6xkHNycx5PPq-PMPSTizom4loj7m4hbm0ieRaXB8YD5v_UTqj-7apFP</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Nakayama, Yujiro</creator><creator>Iijima, Takeru</creator><creator>Inokuchi, Takuhiko</creator><creator>Kojika, Ekumi</creator><creator>Takao, Misato</creator><creator>Takao, Akinari</creator><creator>Koizumi, Koichi</creator><creator>Horiguchi, Shin-ichiro</creator><creator>Hishima, Tsunekazu</creator><creator>Yamaguchi, Tatsuro</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8454-1995</orcidid></search><sort><creationdate>20211001</creationdate><title>Clinicopathological features of sporadic MSI colorectal cancer and Lynch syndrome: a single-center retrospective cohort study</title><author>Nakayama, Yujiro ; Iijima, Takeru ; Inokuchi, Takuhiko ; Kojika, Ekumi ; Takao, Misato ; Takao, Akinari ; Koizumi, Koichi ; Horiguchi, Shin-ichiro ; Hishima, Tsunekazu ; Yamaguchi, Tatsuro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-b3341dce7d395fd2ef3b54b6ce083a6dd609d7ccc539541ded05648462e8c1d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cancer</topic><topic>Cancer Research</topic><topic>Cohort analysis</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Genetic disorders</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microsatellite instability</topic><topic>MLH1 protein</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Patients</topic><topic>Surgical Oncology</topic><topic>Survival</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakayama, Yujiro</creatorcontrib><creatorcontrib>Iijima, Takeru</creatorcontrib><creatorcontrib>Inokuchi, Takuhiko</creatorcontrib><creatorcontrib>Kojika, Ekumi</creatorcontrib><creatorcontrib>Takao, Misato</creatorcontrib><creatorcontrib>Takao, Akinari</creatorcontrib><creatorcontrib>Koizumi, Koichi</creatorcontrib><creatorcontrib>Horiguchi, Shin-ichiro</creatorcontrib><creatorcontrib>Hishima, Tsunekazu</creatorcontrib><creatorcontrib>Yamaguchi, Tatsuro</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep (ProQuest)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakayama, Yujiro</au><au>Iijima, Takeru</au><au>Inokuchi, Takuhiko</au><au>Kojika, Ekumi</au><au>Takao, Misato</au><au>Takao, Akinari</au><au>Koizumi, Koichi</au><au>Horiguchi, Shin-ichiro</au><au>Hishima, Tsunekazu</au><au>Yamaguchi, Tatsuro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathological features of sporadic MSI colorectal cancer and Lynch syndrome: a single-center retrospective cohort study</atitle><jtitle>International journal of clinical oncology</jtitle><stitle>Int J Clin Oncol</stitle><date>2021-10-01</date><risdate>2021</risdate><volume>26</volume><issue>10</issue><spage>1881</spage><epage>1889</epage><pages>1881-1889</pages><issn>1341-9625</issn><eissn>1437-7772</eissn><abstract>Background
The clinical and pathological features of sporadic microsatellite instability-high (MSI) colorectal cancer (CRC) are still unclear. The present study aimed to clarify the clinicopathological features of sporadic MSI CRC in comparison with those of Lynch syndrome (LS) exploratorily.
Methods
The present study was a single-center, retrospective cohort study. Sporadic MSI CRC was defined as MSI CRC with aberrant promoter hypermethylation of the
MLH1
gene, while hereditary MSI CRC was defined colorectal cancer in patients with LS.
Results
In total, 2653 patients were enrolled; of these, 120 (4.5%) had MSI CRC, 98 had sporadic MSI CRC, and 22 had LS. Patients with sporadic MSI CRC were significantly older (
p
< 0.001) than those with LS and had a right-sided colonic tumor (
p
< 0.001) which was pathologically poorly differentiated or mucinous (
p
= 0.025). The overall survival rate was significantly lower in patients with stage I, II or III MSI CRC than in those with LS (
p
= 0.024). However, the recurrence-free survival rate did not differ significantly (
p
= 0.85).
Conclusions
We concluded that patients with sporadic MSI are significantly older, tumors more likely to locate in the right-sided colon, pathologically poorly differentiated or mucinous, and worse overall survival than in those with LS.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><doi>10.1007/s10147-021-01968-y</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8454-1995</orcidid></addata></record> |
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| issn | 1341-9625 1437-7772 |
| language | eng |
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| source | Springer Nature |
| subjects | Cancer Cancer Research Cohort analysis Colorectal cancer Colorectal carcinoma Genetic disorders Medicine Medicine & Public Health Microsatellite instability MLH1 protein Oncology Original Article Patients Surgical Oncology Survival Tumors |
| title | Clinicopathological features of sporadic MSI colorectal cancer and Lynch syndrome: a single-center retrospective cohort study |
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