Association Between Body Weight and Telomere Length Is Predominantly Mediated Through C-Reactive Protein

Abstract Context Both obesity and inflammation are related to accelerated aging. It is not yet known whether inflammation mediates the effects of obesity on aging. Objective This work aims to dissect the direct effect of body mass index (BMI) and its indirect effect through C-reactive protein (CRP)...

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Published in:The journal of clinical endocrinology and metabolism 2021-11, Vol.106 (11), p.e4634-e4640
Main Authors: Gao, Xiao, Li, Shengxu, Dong, Shiqiu, Li, Jiaqi, Yan, Yinkun, Zhang, Tao, Chen, Wei
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging
Analysis
Biomarkers - metabolism
Body Mass Index
Body Weight
C-reactive protein
C-Reactive Protein - metabolism
Cohort Studies
Cotinine
Cross-Sectional Studies
Exercise
Female
Follow-Up Studies
Health surveys
Humans
Inflammation
Inflammation - epidemiology
Inflammation - metabolism
Inflammation - pathology
Leukocytes - metabolism
Leukocytes - pathology
Male
Mediation
Middle Aged
Nutrition Surveys
Obesity
Obesity - complications
Physical activity
Prognosis
Surveys
Telomere - genetics
Telomere - metabolism
Telomeres
United States - epidemiology
Young Adult
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Summary:Abstract Context Both obesity and inflammation are related to accelerated aging. It is not yet known whether inflammation mediates the effects of obesity on aging. Objective This work aims to dissect the direct effect of body mass index (BMI) and its indirect effect through C-reactive protein (CRP) on leukocyte telomere length (LTL) to determine the mediation effect of CRP on the BMI-LTL association. Methods The study cohort included 5451 adults (1404 Mexican American, 3114 White, and 933 Black individuals; 53.5% male; mean age = 49.2 years) from the 1999 to 2002 National Health and Nutrition Examination Survey. General mediation models were used to examine the mediation effect of CRP on the BMI-LTL association. Results After adjusting for age, race, sex, physical activity, alcohol use, and serum cotinine, the total effect of BMI on LTL was significant (standardized regression coefficient, β = –.054, P 
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgab455