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Association Between Body Weight and Telomere Length Is Predominantly Mediated Through C-Reactive Protein
Abstract Context Both obesity and inflammation are related to accelerated aging. It is not yet known whether inflammation mediates the effects of obesity on aging. Objective This work aims to dissect the direct effect of body mass index (BMI) and its indirect effect through C-reactive protein (CRP)...
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| Published in: | The journal of clinical endocrinology and metabolism 2021-11, Vol.106 (11), p.e4634-e4640 |
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| cites | cdi_FETCH-LOGICAL-c464t-fa535ac2745a2820489ca64475488c324d5119b6dd20192ba7eedfdb7c4825613 |
| container_end_page | e4640 |
| container_issue | 11 |
| container_start_page | e4634 |
| container_title | The journal of clinical endocrinology and metabolism |
| container_volume | 106 |
| creator | Gao, Xiao Li, Shengxu Dong, Shiqiu Li, Jiaqi Yan, Yinkun Zhang, Tao Chen, Wei |
| description | Abstract
Context
Both obesity and inflammation are related to accelerated aging. It is not yet known whether inflammation mediates the effects of obesity on aging.
Objective
This work aims to dissect the direct effect of body mass index (BMI) and its indirect effect through C-reactive protein (CRP) on leukocyte telomere length (LTL) to determine the mediation effect of CRP on the BMI-LTL association.
Methods
The study cohort included 5451 adults (1404 Mexican American, 3114 White, and 933 Black individuals; 53.5% male; mean age = 49.2 years) from the 1999 to 2002 National Health and Nutrition Examination Survey. General mediation models were used to examine the mediation effect of CRP on the BMI-LTL association.
Results
After adjusting for age, race, sex, physical activity, alcohol use, and serum cotinine, the total effect of BMI on LTL was significant (standardized regression coefficient, β = –.054, P |
| doi_str_mv | 10.1210/clinem/dgab455 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2544158205</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A702375236</galeid><oup_id>10.1210/clinem/dgab455</oup_id><sourcerecordid>A702375236</sourcerecordid><originalsourceid>FETCH-LOGICAL-c464t-fa535ac2745a2820489ca64475488c324d5119b6dd20192ba7eedfdb7c4825613</originalsourceid><addsrcrecordid>eNqFkc9rFDEUx4NY7Fq9epQBL3qYNj_nx3Fdqha2KFLRW8gkb2ZSZpJtkqnsf2_KrgpSkBwehM_7vPf4IvSK4HNCCb7Qk3UwX5hBdVyIJ2hFWi7KmrT1U7TCmJKyremPU_Q8xluMCeeCPUOnjBPBcMtWaFzH6LVVyXpXvIf0EyBXb_bFd7DDmArlTHEDk58hQLEFN6SxuIrFlwDGz9Ypl6Z9cQ0mKyCTY_DLMBab8isonew9ZNInsO4FOunVFOHlsZ6hbx8ubzafyu3nj1eb9bbUvOKp7JVgQmlac6FoQzFvWq0qzmvBm0Yzyo0gpO0qYygmLe1UDWB609WaN1RUhJ2htwfvLvi7BWKSs40apkk58EuUVPB8fDaLjL75B731S3B5O8lIntkKUbV_qUFNIK3rfQpKP0jlusaU1YKyKlPnj1D5GZit9g56m_8fa9DBxxigl7tgZxX2kmD5EK08RCuP0eaG18dtl24G8wf_nWUG3h0Av-z-J_sFI5ms9g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3164495569</pqid></control><display><type>article</type><title>Association Between Body Weight and Telomere Length Is Predominantly Mediated Through C-Reactive Protein</title><source>Oxford University Press:Jisc Collections:OUP Read and Publish 2024-2025 (2024 collection) (Reading list)</source><creator>Gao, Xiao ; Li, Shengxu ; Dong, Shiqiu ; Li, Jiaqi ; Yan, Yinkun ; Zhang, Tao ; Chen, Wei</creator><creatorcontrib>Gao, Xiao ; Li, Shengxu ; Dong, Shiqiu ; Li, Jiaqi ; Yan, Yinkun ; Zhang, Tao ; Chen, Wei</creatorcontrib><description>Abstract
Context
Both obesity and inflammation are related to accelerated aging. It is not yet known whether inflammation mediates the effects of obesity on aging.
Objective
This work aims to dissect the direct effect of body mass index (BMI) and its indirect effect through C-reactive protein (CRP) on leukocyte telomere length (LTL) to determine the mediation effect of CRP on the BMI-LTL association.
Methods
The study cohort included 5451 adults (1404 Mexican American, 3114 White, and 933 Black individuals; 53.5% male; mean age = 49.2 years) from the 1999 to 2002 National Health and Nutrition Examination Survey. General mediation models were used to examine the mediation effect of CRP on the BMI-LTL association.
Results
After adjusting for age, race, sex, physical activity, alcohol use, and serum cotinine, the total effect of BMI on LTL was significant (standardized regression coefficient, β = –.054, P < .001) without CRP included in the model. With inclusion of CRP in the model, the indirect effect of BMI on LTL through CRP was estimated at β equal to –.023 (P < .001), and the direct effect of BMI on LTL in its absolute value decreased to β equal to –.031 (P = .025). The mediation effect of CRP was estimated at 42.6%. The mediation model parameters did not differ significantly between race and sex groups.
Conclusion
These results suggest that the inverse BMI-LTL association is partly mediated by obesity-induced inflammation. The significant direct effect of BMI on LTL with removal of the mediation effect through CRP indicates that obesity is associated with LTL attrition also through other noninflammatory mechanisms.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/clinem/dgab455</identifier><identifier>PMID: 34153093</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aging ; Analysis ; Biomarkers - metabolism ; Body Mass Index ; Body Weight ; C-reactive protein ; C-Reactive Protein - metabolism ; Cohort Studies ; Cotinine ; Cross-Sectional Studies ; Exercise ; Female ; Follow-Up Studies ; Health surveys ; Humans ; Inflammation ; Inflammation - epidemiology ; Inflammation - metabolism ; Inflammation - pathology ; Leukocytes - metabolism ; Leukocytes - pathology ; Male ; Mediation ; Middle Aged ; Nutrition Surveys ; Obesity ; Obesity - complications ; Physical activity ; Prognosis ; Surveys ; Telomere - genetics ; Telomere - metabolism ; Telomeres ; United States - epidemiology ; Young Adult</subject><ispartof>The journal of clinical endocrinology and metabolism, 2021-11, Vol.106 (11), p.e4634-e4640</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>COPYRIGHT 2021 Oxford University Press</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-fa535ac2745a2820489ca64475488c324d5119b6dd20192ba7eedfdb7c4825613</citedby><cites>FETCH-LOGICAL-c464t-fa535ac2745a2820489ca64475488c324d5119b6dd20192ba7eedfdb7c4825613</cites><orcidid>0000-0003-1048-4443</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34153093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Xiao</creatorcontrib><creatorcontrib>Li, Shengxu</creatorcontrib><creatorcontrib>Dong, Shiqiu</creatorcontrib><creatorcontrib>Li, Jiaqi</creatorcontrib><creatorcontrib>Yan, Yinkun</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><title>Association Between Body Weight and Telomere Length Is Predominantly Mediated Through C-Reactive Protein</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Abstract
Context
Both obesity and inflammation are related to accelerated aging. It is not yet known whether inflammation mediates the effects of obesity on aging.
Objective
This work aims to dissect the direct effect of body mass index (BMI) and its indirect effect through C-reactive protein (CRP) on leukocyte telomere length (LTL) to determine the mediation effect of CRP on the BMI-LTL association.
Methods
The study cohort included 5451 adults (1404 Mexican American, 3114 White, and 933 Black individuals; 53.5% male; mean age = 49.2 years) from the 1999 to 2002 National Health and Nutrition Examination Survey. General mediation models were used to examine the mediation effect of CRP on the BMI-LTL association.
Results
After adjusting for age, race, sex, physical activity, alcohol use, and serum cotinine, the total effect of BMI on LTL was significant (standardized regression coefficient, β = –.054, P < .001) without CRP included in the model. With inclusion of CRP in the model, the indirect effect of BMI on LTL through CRP was estimated at β equal to –.023 (P < .001), and the direct effect of BMI on LTL in its absolute value decreased to β equal to –.031 (P = .025). The mediation effect of CRP was estimated at 42.6%. The mediation model parameters did not differ significantly between race and sex groups.
Conclusion
These results suggest that the inverse BMI-LTL association is partly mediated by obesity-induced inflammation. The significant direct effect of BMI on LTL with removal of the mediation effect through CRP indicates that obesity is associated with LTL attrition also through other noninflammatory mechanisms.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Analysis</subject><subject>Biomarkers - metabolism</subject><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cohort Studies</subject><subject>Cotinine</subject><subject>Cross-Sectional Studies</subject><subject>Exercise</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health surveys</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - epidemiology</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - pathology</subject><subject>Leukocytes - metabolism</subject><subject>Leukocytes - pathology</subject><subject>Male</subject><subject>Mediation</subject><subject>Middle Aged</subject><subject>Nutrition Surveys</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Physical activity</subject><subject>Prognosis</subject><subject>Surveys</subject><subject>Telomere - genetics</subject><subject>Telomere - metabolism</subject><subject>Telomeres</subject><subject>United States - epidemiology</subject><subject>Young Adult</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkc9rFDEUx4NY7Fq9epQBL3qYNj_nx3Fdqha2KFLRW8gkb2ZSZpJtkqnsf2_KrgpSkBwehM_7vPf4IvSK4HNCCb7Qk3UwX5hBdVyIJ2hFWi7KmrT1U7TCmJKyremPU_Q8xluMCeeCPUOnjBPBcMtWaFzH6LVVyXpXvIf0EyBXb_bFd7DDmArlTHEDk58hQLEFN6SxuIrFlwDGz9Ypl6Z9cQ0mKyCTY_DLMBab8isonew9ZNInsO4FOunVFOHlsZ6hbx8ubzafyu3nj1eb9bbUvOKp7JVgQmlac6FoQzFvWq0qzmvBm0Yzyo0gpO0qYygmLe1UDWB609WaN1RUhJ2htwfvLvi7BWKSs40apkk58EuUVPB8fDaLjL75B731S3B5O8lIntkKUbV_qUFNIK3rfQpKP0jlusaU1YKyKlPnj1D5GZit9g56m_8fa9DBxxigl7tgZxX2kmD5EK08RCuP0eaG18dtl24G8wf_nWUG3h0Av-z-J_sFI5ms9g</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Gao, Xiao</creator><creator>Li, Shengxu</creator><creator>Dong, Shiqiu</creator><creator>Li, Jiaqi</creator><creator>Yan, Yinkun</creator><creator>Zhang, Tao</creator><creator>Chen, Wei</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1048-4443</orcidid></search><sort><creationdate>20211101</creationdate><title>Association Between Body Weight and Telomere Length Is Predominantly Mediated Through C-Reactive Protein</title><author>Gao, Xiao ; Li, Shengxu ; Dong, Shiqiu ; Li, Jiaqi ; Yan, Yinkun ; Zhang, Tao ; Chen, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-fa535ac2745a2820489ca64475488c324d5119b6dd20192ba7eedfdb7c4825613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Analysis</topic><topic>Biomarkers - metabolism</topic><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cohort Studies</topic><topic>Cotinine</topic><topic>Cross-Sectional Studies</topic><topic>Exercise</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health surveys</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - epidemiology</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - pathology</topic><topic>Leukocytes - metabolism</topic><topic>Leukocytes - pathology</topic><topic>Male</topic><topic>Mediation</topic><topic>Middle Aged</topic><topic>Nutrition Surveys</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Physical activity</topic><topic>Prognosis</topic><topic>Surveys</topic><topic>Telomere - genetics</topic><topic>Telomere - metabolism</topic><topic>Telomeres</topic><topic>United States - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Xiao</creatorcontrib><creatorcontrib>Li, Shengxu</creatorcontrib><creatorcontrib>Dong, Shiqiu</creatorcontrib><creatorcontrib>Li, Jiaqi</creatorcontrib><creatorcontrib>Yan, Yinkun</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Xiao</au><au>Li, Shengxu</au><au>Dong, Shiqiu</au><au>Li, Jiaqi</au><au>Yan, Yinkun</au><au>Zhang, Tao</au><au>Chen, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Body Weight and Telomere Length Is Predominantly Mediated Through C-Reactive Protein</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>106</volume><issue>11</issue><spage>e4634</spage><epage>e4640</epage><pages>e4634-e4640</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Abstract
Context
Both obesity and inflammation are related to accelerated aging. It is not yet known whether inflammation mediates the effects of obesity on aging.
Objective
This work aims to dissect the direct effect of body mass index (BMI) and its indirect effect through C-reactive protein (CRP) on leukocyte telomere length (LTL) to determine the mediation effect of CRP on the BMI-LTL association.
Methods
The study cohort included 5451 adults (1404 Mexican American, 3114 White, and 933 Black individuals; 53.5% male; mean age = 49.2 years) from the 1999 to 2002 National Health and Nutrition Examination Survey. General mediation models were used to examine the mediation effect of CRP on the BMI-LTL association.
Results
After adjusting for age, race, sex, physical activity, alcohol use, and serum cotinine, the total effect of BMI on LTL was significant (standardized regression coefficient, β = –.054, P < .001) without CRP included in the model. With inclusion of CRP in the model, the indirect effect of BMI on LTL through CRP was estimated at β equal to –.023 (P < .001), and the direct effect of BMI on LTL in its absolute value decreased to β equal to –.031 (P = .025). The mediation effect of CRP was estimated at 42.6%. The mediation model parameters did not differ significantly between race and sex groups.
Conclusion
These results suggest that the inverse BMI-LTL association is partly mediated by obesity-induced inflammation. The significant direct effect of BMI on LTL with removal of the mediation effect through CRP indicates that obesity is associated with LTL attrition also through other noninflammatory mechanisms.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>34153093</pmid><doi>10.1210/clinem/dgab455</doi><orcidid>https://orcid.org/0000-0003-1048-4443</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Aging Analysis Biomarkers - metabolism Body Mass Index Body Weight C-reactive protein C-Reactive Protein - metabolism Cohort Studies Cotinine Cross-Sectional Studies Exercise Female Follow-Up Studies Health surveys Humans Inflammation Inflammation - epidemiology Inflammation - metabolism Inflammation - pathology Leukocytes - metabolism Leukocytes - pathology Male Mediation Middle Aged Nutrition Surveys Obesity Obesity - complications Physical activity Prognosis Surveys Telomere - genetics Telomere - metabolism Telomeres United States - epidemiology Young Adult |
| title | Association Between Body Weight and Telomere Length Is Predominantly Mediated Through C-Reactive Protein |
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